Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine

Kviecinski, Maicon Roberto; Schoenfelder, Tatiana; Wiese, Luiz Paulo de Lemos; Rossi, Maria Helena Wagner; Gonçalez, Edlayne; Felício, Joana D.; Filho, Danilo Wilhelm; Pedrosa, Rozangela Curi

doi:10.1016/j.jep.2008.01.017

Cited by 124 publications

(78 citation statements)

References 16 publications

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“…The contribution of new and novel products from potential bioactive plants or their extracts for disease treatment and prevention is still vast, despite the overshadowing by recent synthetic chemistry as a method of drug discoveries and drug productions [5] . Moreover, plant derived drugs like vinblastine, vincristine, taxol, and camptothecin had lead to greatest extend within the vicinity of antitumor upon where, the drugs were reported to improvise the chemotherapy of some cancers [6] .…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

Vijayarathna

Sasidharan

2012

Asian Pacific Journal of Tropical Biomedicine

133

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

Vijayarathna

Sasidharan

2012

Asian Pacific Journal of Tropical Biomedicine

133

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“…These results demonstrate the importance of this plant family in the control of other snail species. The species Bidens pilosa Linné (Asteraceae) popularly known as hairy beggarticks, is a herbaceous plant with a short annual cycle (Lorenzi 2000) widely distributed in Brazilian territory, being used in folk medicine (Adegas et al 2003) for antimicrobial (Rojas et al 2006, Deba et al 2008), hepatoprotective (yuan et al 2008, diabetes (Chien et al 2009) andulcer (Freise 1933) antitumoral (Kumari 2009, Kviecinski et al 2008 and antioxidant (Krishnaiah et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Preliminary phytochemical screening and molluscicidal activity of the aqueous extract of Bidens pilosa Linné (Asteraceae) in Subulina octona (Mollusca, Subulinidade)

Souza

Silva

Chicarino

et al. 2013

An. Acad. Bras. Ciênc.

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The aim of this study was to establish reference concentrations (LC 50 e LC 90 ) of aqueous extracts of Bidens pilosa on the land snail Subulina octona, in order to assess the changes caused by 24 and 48 h exposure to the sublethal concentration regarding species' fecundity, hatchability and in offspring produced after exposure to confirm the presence of tannins, saponins and flavonoids in this plant species. Eggs newly hatched and 30 day-old snails were exposed to sublethal concentration, calculated for adults. The phytochemical analysis confirmed the presence of flavonoids, condensed tannins and saponins in the aqueous extract of B. pilosa. The LC 50 and LC 90 obtained were 51.4mg/mL and 74.1mg/mL respectively. The exposure to sublethal concentration reduced significantly the hatchability and the survival of the offspring hatched from exposed eggs and also caused a reduction on survival and growth in snails exposed for both time period. The exposure time also caused a reduction at the evaluated parameters.

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“…The cells were maintained at a density of 1-2 Â 10 6 cells/mL (96-well plate) at 37 C, in 5% CO 2 and 95% humidity (Kviecinski et al, 2008). The cytotoxicity of C. celtidifolius latex in EAC and MCF-7 cells was measured using the MTT assay (Mosmann, 1983).…”

Section: Endpoint Of Cytotoxicitymentioning

confidence: 99%

“…Brazil's biodiversity is a rich source of medicinal plants, and while a number of plant extracts are used against diseases in traditional medicines, only a few of these have been investigated scientifically (Kviecinski et al, 2008). Nonetheless, many of these plants have been used for the treatment of several ailments, including proliferative diseases such as cancer.…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of flavonol and flavan-3-ol rich extracts fromCroton celtidifoliuslatex

Biscaro

Parisotto

Zanette

et al. 2013

Pharmaceutical Biology

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Context: Croton celtidifolius Baill (Euphorbiaceae) is a tree found in the Atlantic Forest in Southern Brazil, where it is commonly known as ''Sangue-de-Dragão''. Its red latex is used traditionally for treating ulcers, diabetes and cancer. Objective: To evaluate antitumor activities of Croton celtififolius latex in vitro and in vivo. Material and methods: Phytochemical analyses were conducted using HPLC-DAD-MS. Cytotoxic, nuclease and pro-apoptotic properties were determined using the tetrazolium salt assay (MTT), plasmid DNA damage assay and ethidium bromide (EB)/acridine orange methods, respectively, and antitumor activity was determined in the Ehrlich ascites carcinoma (EAC) mouse model. Results: Phytochemical studies indicated a high phenol content of flavonols (45.67 AE 0.24 and 18.01 AE 0.23 mg/mL of myricetin and quercetin, respectively) and flavan-3-ols (114.12 AE 1.84 and 1527.41 AE 16.42 mg/L of epicatechin and epigallocatechin, respectively) in latex. These compounds reduced MCF-7 and EAC cell viability in the MTT assay (IC 50 ¼ 169.0 AE 1.8 and 187.0 AE 2.2 mg/mL, respectively). Latex compounds caused significant DNA fragmentation and increased the number of apoptotic cells (negative control (NC), 12%; latex, 41%) as indicated by differential staining in the EB/acridine orange assay. The in vivo latex treatment at 3.12 mg/kg/day reduced the body weight by 7.57 AE 2.04 g and increased median survival time to 17.5 days when compared to the NC group (13.0 days). In addition, the highest latex concentration inhibited tumor growth by 56%. Discussion and conclusion: These results agree with ethno-pharmacological reports showing cytotoxicity and antitumor activity of C. celtidifolius latex. The mechanism of antitumor action may be related to direct DNA fragmentation that reduces survival and induces apoptosis.

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Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine

Cited by 124 publications

References 16 publications

Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

Preliminary phytochemical screening and molluscicidal activity of the aqueous extract of Bidens pilosa Linné (Asteraceae) in Subulina octona (Mollusca, Subulinidade)

Anticancer activity of flavonol and flavan-3-ol rich extracts fromCroton celtidifoliuslatex

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