Study of the antimicrobial activity of metal complexes and their ligands through bioassays applied to plant extracts

Santos, Antônio Fernando Amatto Botelho dos; Brotto, Débora F.; Favarin, Lis Regiane Vizolli; Cabeza, Natália Aparecida; Andrade, Geziel R.; Batistote, Margareth; Cavalheiro, Alberto Adriano; Neves, Ademir; Rodrigues, Daniela Cristina Manfroi; Anjos, Ademir dos

doi:10.1016/j.bjp.2014.07.008

Cited by 70 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data suggested that these complexes were ionic in nature and they were 1:1 electrolytes. The Fe (III) complex had a molar conductivity value of 105.90 Ω −1 mol −1 cm 2 , which suggested that this complex was ionic in nature and it was a 1:2 electrolyte …”

Section: Resultsmentioning

confidence: 99%

Transition metal complexes of Schiff base ligand based on 4,6‐diacetyl resorcinol

Mahmoud

Omar

Ahmed

2020

Applied Organom Chemis

View full text Add to dashboard Cite

Novel Schiff base ligand based on the condensation of 4,6‐diacetyl resorcinol with 2‐amino‐4‐methylthiazole in addition to its metal complexes with Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II) and Cd (II) ions have been synthesized. The structure, electronic properties, and thermal behaviour of Schiff base and its metal complexes have been studied by elemental analysis, mass, 1H NMR, IR spectra, thermal analysis, and theoretically by density function theory. The ligand acted as mononegative bidentate (NO) ligand and all complexes showed octahedral geometry except Cu (II) showed tetrahedral geometry as indicated from the spectral and magnetic studies. The Cu (II), Zn (II) and Cd (II) complexes were non electrolytes while the rest of the complexes were electrolytes. The antibacterial plus anticancer activities of the parent Schiff base and its metal complexes were screened. In addition, the molecular docking study was performed to explore the possible ways for binding to Crystal Structure of Human Astrovirus capsid protein (5ibv) receptor.

show abstract

Section: Resultsmentioning

confidence: 99%

Transition metal complexes of Schiff base ligand based on 4,6‐diacetyl resorcinol

Mahmoud

Omar

Ahmed

2020

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…14 Studies showed that the biological activity of free ligands sometimes become enhanced upon coordination with metal ions. [15][16][17][18][19][20][21] Stable chelates are formed with Schiff bases containing multiple donor atoms, notably bis(orthohydroxybenzylidene)diamines (N 2 O 2 ) ligands. 22,23 The presence of the heterocyclic ring in the Schiff base moiety lends additional stability to the structure of Schiff base metal complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological study of Cu(II) complexes of aminopyridine and (aminomethyl)pyridine Schiff bases

Sobola

Watkins

Brecht

2018

JSCS

View full text Add to dashboard Cite

The synthesis, characterization and antimicrobial activity determination of some aminopyridine-and (aminomethyl)pyridine-salicylaldimine copper(II) complexes were realized. The ligands, L 1-L 6 , were prepared by condensing salicylaldehyde and o-vanillin with 2-and 3-amino-and (aminomethyl)pyridine, respectively. The complexes were characterized by micro-analytical, electronic, infrared and conductivity data. The structures of the Schiff base ligands were further confirmed from 1 Hand 13 C-NMR spectral data. This study established that salicylaldimine ligands could coordinate as neutral species via the imine-N and the undeprotonated phenolic-O. The complexes have the molecular formula: [CuLCl], [Cu(LH) 2 Cl 2 ]•xH 2 O or [Cu(LH)Cl(H 2 O)]Cl. The X-ray crystal structure of [CuL 6 Cl] indicated a square planar geometry with the Schiff base ligand coordinated to the Cu(II) ion as a tridentate monobasic, N 2 O, ligand. The crystals crystallized in a monoclinic system with P2 1 /c space group. All the ligands and their Cu(II) complexes were screened for their antimicrobial activity against Staphylococcus aureus subsp. aureus ATCC ® 6538™  , Bacillus subtillis subsp. spizizenii ATCC ® 6633™  , Escherichia coli ATCC ® 8739™  and Candida albicans ATCC ® 2091™  using agar diffusion and broth dilution techniques. The presence of the methoxyl group enhanced the antimicrobial activity of the salicylaldimine Schiff base ligands.

show abstract

“…When we compare these findings with antibacterial activity of complex 1 [27], it can be concluded that the ligand abb and especially its nickel complex have much better activities against S. aureus and comparable antibacterial activity on E. coli. One should expect higher antibacterial activity in compounds containing sulfur in the structure, but conformation, i.e., planarity vs. nonplanarity of ligands and possible π-π interactions play a very important role in binding to active sites [33,34].…”

Section: Antibacterial Activitymentioning

confidence: 99%

An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

2020

View full text Add to dashboard Cite

The electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni3(abb)3(H2O)3(µ-ttc)](ClO4)3 (1), [Ni3(tebb)3(H2O)3(µ-ttc)](ClO4)3·H2O (2), and [Ni3(pmdien)3(µ-ttc)](ClO4)3 (3), where abb = 1-(1H-benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methan-amine, ttcH3 = trithiocyanuric acid, tebb = 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole, and pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine is reported. Cyclic voltammetry (CV) was applied for the study of the electrochemical behavior of these compounds. The results confirmed the presence of ttc and nickel in oxidation state +2 in the synthesized complexes. Moreover, the antibacterial properties and cytotoxic activity of complex 3 was investigated. All the complexes show antibacterial activity against Staphylococcus aureus and Escherichia coli to different extents. The cytotoxic activity of complex 3 and ttcNa3 were studied on G-361, HOS, K-562, and MCF7 cancer cell lines. It was found out that complex 3 possesses the cytotoxic activity against the tested cell lines, whereas ttcNa3 did not show any cytotoxic activity.

show abstract

Study of the antimicrobial activity of metal complexes and their ligands through bioassays applied to plant extracts

Cited by 70 publications

References 12 publications

Transition metal complexes of Schiff base ligand based on 4,6‐diacetyl resorcinol

Transition metal complexes of Schiff base ligand based on 4,6‐diacetyl resorcinol

Synthesis, characterization and biological study of Cu(II) complexes of aminopyridine and (aminomethyl)pyridine Schiff bases

An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

Contact Info

Product

Resources

About