The synthesis, characterization and antimicrobial activity determination of some aminopyridine-and (aminomethyl)pyridine-salicylaldimine copper(II) complexes were realized. The ligands, L 1-L 6 , were prepared by condensing salicylaldehyde and o-vanillin with 2-and 3-amino-and (aminomethyl)pyridine, respectively. The complexes were characterized by micro-analytical, electronic, infrared and conductivity data. The structures of the Schiff base ligands were further confirmed from 1 Hand 13 C-NMR spectral data. This study established that salicylaldimine ligands could coordinate as neutral species via the imine-N and the undeprotonated phenolic-O. The complexes have the molecular formula: [CuLCl], [Cu(LH) 2 Cl 2 ]•xH 2 O or [Cu(LH)Cl(H 2 O)]Cl. The X-ray crystal structure of [CuL 6 Cl] indicated a square planar geometry with the Schiff base ligand coordinated to the Cu(II) ion as a tridentate monobasic, N 2 O, ligand. The crystals crystallized in a monoclinic system with P2 1 /c space group. All the ligands and their Cu(II) complexes were screened for their antimicrobial activity against Staphylococcus aureus subsp. aureus ATCC ® 6538™  , Bacillus subtillis subsp. spizizenii ATCC ® 6633™  , Escherichia coli ATCC ® 8739™  and Candida albicans ATCC ® 2091™  using agar diffusion and broth dilution techniques. The presence of the methoxyl group enhanced the antimicrobial activity of the salicylaldimine Schiff base ligands.

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Der potentiell dreizähnige Ligand N ,N,N ′,N ′‐Tetramethylpyridin‐2,6‐dicarboxamid, der durch Umsetzung von überschüssigem Dimethylamin mit Pyridin‐2,6‐dicarbonsäuredichlorid in Benzol in 80%iger Ausbeute entsteht, bildet mit Cu(II)‐chlorid den quadratisch‐pyramidalen Komplex (I).