Study of the alkaloid composition of the food‐infecting penicilles

Abstract

Over 30 strains of various Penicillium sp. isolated from food have been screened for the ability to synthesize mycotoxins of an alkaloid nature. The most productive were P. expansum, P. raciborskii, P. puberulum, P. commune, P. viridicatum, P. chrysogenum, P. palitans, P. purpurescens and P. cyclopium. The separate components of the alkaloid mixtures have been isolated and identified. The range of metabolites synthesized by different strains of the same species was considerably expanded. New producers of aurantioclavine, meleagrin, roquefortine, rugulovasine, clavine alkaloids and some other compounds have been found. It was shown that the alkaloid composition and content were dependent on the medium, culture age and method of cultivation.

Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

“…966 A convergent stereospecific synthesis followed in 2002 by Selle `s and Lett. 967 Queenslandon (357), an antifungal agent produced by Chrysosporium queenslandicum (class of Ascomycetes), 968 and the Aigialomycins 654 resemble more closely the zearalenone family. Several approaches exist in order to achieve total synthesis, e.g., a concise strategy to the core structure (macrolide) of Queenslandon ( 357) by Maier et al from the year 2006.…”