Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

Bräse, Stefan; Encinas, Arantxa; Keck, Julia; Nising, Carl F.

doi:10.1021/cr050001f

Cited by 525 publications

(315 citation statements)

References 1,267 publications

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“…In recent years, more and more dibenzo-α-pyrones have been isolated from plant endophytic fungi. These endophytic fungi could be the rich sources of biologically active compounds that are indispensable for medicinal and agricultural applications [92,93]. In most cases, biological activities, structure-activity relationships, and modes of action of dibenzo-α-pyrones were only primarily investigated.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Natural Dibenzo-α-Pyrones and Their Bioactivities

Mao

Sun

et al. 2014

Molecules

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Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Natural Dibenzo-α-Pyrones and Their Bioactivities

Mao

Sun

et al. 2014

Molecules

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“…IR spectra were recorded on a EQUINOX-55 spectrometer in a KBr matrix. 1 H NMR spectra were recorded on a INOVA-400 NMR spectrometer, using TMS as internal standard and CDCl 3 as solvent. Elemental analyses were performed on a Vario EL III CHNOS analyzer.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of Three Novel Nitrogen-containing Macrolides

Leng

Yang

Liu

et al. 2011

Zeitschrift Für Naturforschung B

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Three novel nitrogen-containing macrolides have been synthesized by esterification. All of them have been characterized by infrared (IR), elemental analysis, mass spectra (MS), and 1 H NMR spectroscopy, and their crystal structures were determined by single-crystal X-ray diffraction. The preparation methods and the intermolecular associations based on C-H···O hydrogen bonds and π-π stacking interactions are discussed.

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“…enniatins and several other mycotoxins or emerging mycotoxins (Brase et al, 2009;Gruber-Dorninger et al, 2017;Neme and Mohammed, 2017). Since moniliformin is produced by so many species one can maybe expect that apart from its mammal and plant toxicity, it could have antibiotic or quorum sensing inhibition abililites.…”

Section: Penicillium Madritimentioning

confidence: 99%

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad

2018

WMJ

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A very large number of filamentous fungi has been reported to produce the small lactone mycotoxins patulin, penicillic acid and moniliformin. Among the 167 reported fungal producers of patulin, only production by 29 species could be confirmed. Patulin is produced by 3 Aspergillus species, 3 Paecilomyces species, 22 Penicillium species from 7 sections of Penicillium, and one Xylaria species. Among 101 reported producers of penicillic acid, 48 species could produce this mycotoxin. Penicillic acid is produced by 23 species in section Aspergillus subgenus Circumdati section Circumdati, by Malbranchea aurantiaca and by 24 Penicillium species from 9 sections in Penicillium and one species that does not actually belong to Penicillium (P. megasporum). Among 40 reported producers of moniliformin, five species have been regarded as doubtful producers of this mycotoxin or are now regarded as taxonomic synonyms. Moniliformin is produced by 34 Fusarium species and one Penicillium species. All the accepted producers of patulin, penicillic acid and moniliformin were revised according to the new one fungus – one name nomenclatural system, and the most recently accepted taxonomy of the species.

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Chemistry and Biology of Mycotoxins and Related Fungal Metabolites

Cited by 525 publications

References 1,267 publications

Natural Dibenzo-α-Pyrones and Their Bioactivities

Natural Dibenzo-α-Pyrones and Their Bioactivities

Synthesis and Characterization of Three Novel Nitrogen-containing Macrolides

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

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