Study of Serum Antibodies Against Three Eye Muscle Antigens and the Connective Tissue Antigen Collagen XIII in Patients with Graves' Disease With and Without Ophthalmopathy: Correlation With Clinical Features

Abstract

Calsequestrin and collagen XIII antibodies are the most specific to TAO, whereas antibodies against G2s, and to a lesser extent Fp, are also markers of ophthalmopathy, but less reliable. These results are unique in that it is the first time the significance of a panel of three candidate eye muscle antibodies and a connective tissue antibody have been evaluated in the same patients with ophthalmopathy.

IgG4-related Ocular Adnexal Disease Mimicking Thyroid-associated Orbitopathy

“…Notably, in patients with TAO, alpha fodrin may be one of the autoantigens involved in both the salivary glands and orbit (16) and thus may have been responsible for the symptoms observed in our patient. In addition, calsequestrin, collagen XIII, IGF-1 receptor and TSH receptor have been proposed to be antigens involved in the pathogenesis of TAO (17,18). Further investigations are warranted to identify common autoantigens among autoimmune thyroid diseases, ocular adnexal diseases and IgG4-RD.…”

An update on thyroid-associated ophthalmopathy in children and adolescents

“…in chronic lymphocytic thyroiditis. In these patients factors leading to pathologic changes may include antibodies against ocular muscle antigens: calsequestrin, collagen XIII, flavoprotein (Fp) and protein G2s [24]. Oxidative stress may also have a negative influence on the course of TAO.…”

Factors associated with outcome after combined steroid and orbital radiotherapy on Graves’ ophthalmopathy

“…18 As the factors concerning the onset, severity, and drug responsiveness of TAO are yet uncertain and the role that hyperthyroidism management may play on TAO's emergence and development are also unclear, TAO management remains a key research topic. 19 In this review, we found therapeutic indication for TAO in 53 out of 167 patients. The remainders who showed no medical signs judging from CAS and MRI had missed their particular window of responsiveness to treatment mainly due to a gap between pathological activities and clinical symptoms.…”