Study of biomineralization of poly(vinyl alcohol)‐based scaffolds using an alternate soaking approach

Abstract

The present work adds to the continuing efforts of designing a natural bone-like structure by synthesizing a semi-interpenetrating polymer network (IPN) of poly(vinyl alcohol)-poly[(acrylic acid)-co-acrylonitrile] and impregnating hydroxyapatite (HAP) into the polymer matrix by an alternate soaking process. The prepared HAP-polymer scaffolds were characterized using techniques like Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis and environmental scanning electron microscopy. The biomineralized semi-IPN was evaluated for water sorption capacity and the data were utilized for calculating network parameters such as average molecular weight between crosslinks (M c ) and crosslink density (q). The impregnated HAP was quantified as a function of the chemical architecture of the semi-IPN, number of reaction cycles and temperature of the swelling bath.

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

“…Surfaces containing PEG are interesting biomaterials because they exhibit low degrees of protein adsorption and cell adhesion. [14][15][16] PEG is also well known for its extraordinary ability to resist protein adsorption because of its hydrophilicity and unique coordination with surrounding water molecules in an aqueous medium.…”

Surface characteristics of poly(γ‐alkyl α l‐glutamate)s with different alkyl groups

“…Among them, it is widely accepted that hydrophobic interaction between the polymer surface and protein plays a significant role in the nonselective adsorption of protein. [31][32][33][34][35][36][37] Usually, that is, polymers possessing hydrophilic surface show relatively low nonselective protein adsorption. Albumin is the major constituent of blood plasma and is one of the smallest plasma proteins with molecular weight of 67 kDa which adsorbs to the surface fast.…”

Evaluation of water sorption behavior and in vitro blood compatibility of polyvinyl alcohol based magnetic bionanocomposites

“…The extent of swelling of grafted hydrogel was determined by a conventional gravimetric procedure as reported in literature 36. In a typical experiment, preweighed pieces of hydrogel (without iron oxide) were allowed to swell in distilled water for 24 h (up to equilibrium swelling).…”