Evaluation of water sorption behavior and in vitro blood compatibility of polyvinyl alcohol based magnetic bionanocomposites

Abstract

In recent past magnetic bionanocomposites have shown potential in biomedical applications mainly due to their superparamagnetic and biocompatible nature. They have also established themselves as a promising class of hybrid organic-inorganic materials derived from polymers and organic/inorganic fillers. In this study biocompatible nanocomposites were prepared by in situ synthesis of magnetic nanoparticles within the polyvinyl alcohol-grafted-polymethyl methacrylate hydrogels and characterized by techniques such as FT-IR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and differential scanning calorimetry. The bionanocomposites were evaluated for water sorption behavior and in vitro biocompatibility by performing thrombus formation and hemolysis tests. The influence of chemical composition of the grafted hydrogel was investigated on water sorption behavior and in vitro blood compatibility of magnetic bionanocomposites.

Polymer-Nanoparticle Composites: From Synthesis to Modern Applications

“…Application potential for superparamagnetic nanocomposites was found as microwave absorbing material [ 64 ]. Very recent and advanced developments of organic coated magnetic nanoparticles show application potential mainly in biology, medicine, in biomedicine [ 54 , 159 , 160 , 161 , 162 ], and diagnostics, such as contrast agent for MRI (magnetic resonance imaging) [ 163 , 164 ], in cancer treatment by local hyperthermia [ 165 , 166 , 167 ], as drug carriers [ 168 , 169 , 170 ] or as biocompatible ferromagnetic fluid [ 53 , 171 ].…”

“…Fluorescent, stable aqueous ZnOat Polymer core/shell nanoparticles exhibit a high potential for application as fluorescent probes in vitro , as they are almost nontoxic for human cells [ 139 ]. Finally, as already shown in section 6.2 ., there is a huge application potential for superparamagnetic nanocomposites in the field of biology, medicine, diagnostics and therapy [ 53 , 54 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 ].…”

Influence of heat treatment on phase transformation of clay–iron oxide composite

“…Preparation and magnetic properties of silica coated nanoparticles were studied by Mazaleyrat et al [6], synthesis and size-modulation of silica coated maghemite nanoparticles were described by Almeida et al [7]. Characterization of magnetite (Fe 3 O 4 )/polyvinyl alcohol-based nanocomposites and study of their in vitro blood compatibility were published by Bajpai et al [8,9]. Amino acid-coated magnetic nanoparticles which might be applied to cell separation, diagnosis and targeted drug delivery for cancer therapy were investigated by Durmus et al [10].…”

Effect of cross-linker and dopant concentrations on the magnetic properties of poly(vinyl alcohol)-borax ferrogels

“…1 and 2, the ferrogels are observed to exhibit characteristics of soft magnetic materials. PVA hydrogel matrices are known to exhibit diamagnetic behaviour while CI is a magnetically soft material [10,14]. The magnetically soft behaviour of the studied systems arises from the presence of CI particles within the hydrogel matrices.…”