Studies with aspirin: Psychopharmacologic and methodologic considerations

Krumholz, W; Sheppard, Charles; Merlis, Sidney

doi:10.1002/cpt196456part1691

Cited by 5 publications

(6 citation statements)

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“…As a main effect, aspirin had no significant effects on any of the six moods. This observation conflicts with the conclusions but not with the results of studies reporting such effects (Krumholz et al, 1964(Krumholz et al, , 1965Pfeiffer et al, 1967). Present data suggest that the previous studies were misleading because they employed an excessively narrow range of instructional contexts.…”

Section: Discussioncontrasting

confidence: 99%

“…The present results can be most directly compared to those by Krumholz, Sheppard, and Merlis (1964), who obtained mood scale data from 5s who were apparently expecting a mild tranquilizer or antidepressant. Compared to placebo, they found aspirin to reduce the Unhappy score on the Clyde Mood Scale and to reduce fearfulness and depression scores on a discomfort scale.…”

Section: Discussionmentioning

confidence: 51%

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Modification of placebo effects by means of drugs: Effects of aspirin and placebos on self-rated moods.

Dinnerstein¹,

Halm²

1970

Journal of Abnormal Psychology

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How do drugs and placebos interact? As a model experiment, changes in selfrated mood were measured in four treatment groups. The Ss in each group received either aspirin or lactose, plus a placebo liquid described to 5s as being either a "tranquilizer" or an "energizer." Aspirin had no significant main effect on mood, but did cause significant changes in the placebo effects, adding dimensions of friendly intoxication to the tranquilizer effect and of asocial sobriety to the energizer effect. These results, plus analogous results in other studies, argue that Ss' expectancies concerning treatment effects should be manipulated in any study of potentially psychoactive drugs.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 51%

Modification of placebo effects by means of drugs: Effects of aspirin and placebos on self-rated moods.

Dinnerstein¹,

Halm²

1970

Journal of Abnormal Psychology

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“…In an earlier study of the comparative "tranquilizing" effects of aspirin, a placebo, a mild tranquilizer, and an aspirin compound, the last was found to be the most effective in reducing fearfulness and depression. 3 The action of the aspirin compound was not of a high order but the level of significance of the data indicated the findings were not likely to be due to chance.…”

Section: The Clinical and Research Facilities Of The Central Islip Stmentioning

confidence: 95%

“…:t were the same as those in the first study. 3 The rating data were processed by a complex analysis of variance to measure the effects of the individual medications.…”

Section: Methodsmentioning

confidence: 99%

Studies with aspirin: Psychopharmacologic and methodologic considerations

Krumholz

Sheppard

Merlis

1964

Clin Pharma and Therapeutics

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“…This symptom is of interest because of the popular concept that aspirin helps to induce sleep, even in subjects without pain. This idea is based on experience rather than formal trial, but there are several interesting references in the literature to the sedative or tranquil-]izing properties of aspirin (Kaufman, 1927 ;Lespagnol et al, 1963;Krumholz et al, 1964Krumholz et al, , 1965Pfeiffer et al, 1965). It would appear that this sedative property is enhanced in the derivative we have been studying, viz., 3MS.…”

Section: Toxic Effects Of 3msmentioning

confidence: 99%

The effect of 3-methyl salicylic (0-cresotinic) acid on plasma insulin and glucose tolerance in diabetic and non-diabetic subjects

et al. 1971

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Oral administration of 3-methyl salicylic acid (3MS) to diabetic and non-diabetic patients in modest doses (0.9-1.8 g/day) over several months produced a significant increase in plasma insulin levels, one hour after a glucose load. In 2 diabetic subjects, acute doses had a similar effect.-Improvement in glucose tolerance after chronic administration of 3MS to diabetic patients was inconsistent, and could not be conclusively related to the action of the drug. Although acute doses of 31~{S caused a fall in plasma FFA after 3-6h, chronic treatment gave no predictable change in fasting plasma FFA levels.-Because of side effects, 3MS was not considered suitable for introduction as a therapeutic agent. The results, however, are of academic interest since it is the first demonstration of increased plasma insulin after an oral salicylate. Effet de l'aeide 3-m~thyl salicylique (O-crdsotinique) sur l'insuline plasmatique et la tolerance au glucose chez des sujets diabdtiques et non-diabdtiques R~sumg. L'administration orale d'acide 3-mdthyl salieylique (3MS) k des sujets diab6tiques et non-dia-b6tiques, ~ faibles doses (0.9-1.8 g/jour) pendant plusieurs mois produisait une augmentation signifieative des taux d'insuline plasmatique, une heure apr~s une charge ell glucose. Chez 2 sujets diabdtiques, des doses aigu~s avaient un effct semblable.-Une am6lioration de la tol6ranee au glucose, apr~s administration chronique de 3MS ~ des patients diabdtiques, n'a pas dtg ddcelde et n'a pas pu ~tre relide ~ Faction de la drogue de fa~on coneluante. Bien que des doses aigu~s de 31ViS provoquassent une chute des FFA plasmatiques au bout de 3-6 hs, le traitement chronique ne causait pas de modification prdvisible des taux plasmatiques de FFA k jeun.-A cause des effets secondaires, le 31VIS n'a pas ~tg jugd valable en rant qu'agent thdrapeutique. Les rgsultats cependant, sent d'intdr6t acaddmique, car c'est la premiere d~monstration d'une glgvation de l'insuline plasmatique apr~s administration orMe d'un salicylate. Wirleung der 3-Methyl-Salieyl (O-Kresotin) Sdure auf das Plasmainsulin und die Glucosetoleranz bei Diabetil~ern and Nichtdiabetilcern Die orale Zufuhr yon 3-iYiethyl-Salieyls~iure (31VLS) in relativ niedrigen Dosen (0.9-1.8 g/Tag) an Diabetiker und stoffwechselgesunde Patienten fiber mehrere Monate ffihrte zu einem signifikanten Ansticg der Plasmainsulinspiegel eine Stunde nach Glucosebelastung. Bei 2 Diabetikern riefen akute Gaben einen ~hnliehen Effekt hervet.-Die Besserung der Glucosetoleranz nach chroniseher 3 MS Verabreiehung an Diabetiker war nur vorfibergehend und konnte nicht init Sicherheit auf das 1Viedikament zurfickgeffihrt werden. Obwohl es 3-6 Std nach akuten Gaben yon 31V~S zu einem Abfall der FFS-Konzentrationen im Plasma kam, 15ste die chronisehe Zufuhr keine vorhersagbaren Ver~nderungen.der FFS-Spiegel im Nfichtern-Plasma aus.-Wegen selner Nebenwirkungen erscheint uns die 3i~S zur Einffihrung in die Therapie nicht als geeignet. Die Ergebnisse sind aber yon akademischem Interesse, da mit ihnen zum ersten lVi...

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Studies with aspirin: Psychopharmacologic and methodologic considerations

Cited by 5 publications

References 1 publication

Modification of placebo effects by means of drugs: Effects of aspirin and placebos on self-rated moods.

Modification of placebo effects by means of drugs: Effects of aspirin and placebos on self-rated moods.

Studies with aspirin: Psychopharmacologic and methodologic considerations

The effect of 3-methyl salicylic (0-cresotinic) acid on plasma insulin and glucose tolerance in diabetic and non-diabetic subjects

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