In this communication we report an attempt to verify the findings of a previous report comparing the “rtranquilizing and antidepressant” effects of aspirin, an aspirin compound, a mild tranquilizer, and a placebo on 20 volunteer subjects. In a double‐blind, Latin‐square comparison, slightly different from the first design, the “antidepressant” effects of aspirin were verified. Some comments are made on the problems of subject selection in psychopharmacologic studies. The need for further study of the “tranquilizing and antidepressant” effects of aspirin is indicated.
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