Studies on the mechanism of protective effects of selenium against the toxicity of methylmercury.

Yamane, Yasuhiro; Fukino, Hideki; Aida, Yukio; Imagawa, Masayoshi

doi:10.1248/cpb.25.2831

Cited by 29 publications

(8 citation statements)

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“…In other studies simultaneous administration of selenium was reported to result in significant changes in the distribution of methylmercury in the body (34,41,45). There are also reports stating that if selenium affects the methylmercury concentration in the blood at all, it re-sults in a decrease rather than an increase (52) and that this effect is attributable to a selenium-induced decrease in the affinity of red blood cells for methylmercury (52).…”

Section: Introductionmentioning

confidence: 94%

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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Section: Introductionmentioning

confidence: 94%

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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“…It can therefore be concluded that selenium does not accelerate the dealkylation of alkylmercurials as it was suggested for methylmercury by Yamane et al. (80).…”

Section: Discussionmentioning

confidence: 65%

Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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The biotransformation efficiency of alkylmercurial compounds was studied in rat liver, kidneys, blood, and brain after 2-week administration of methylmercuric chloride (MeHg) and ethylmercuric chloride (EtHg) at doses of 0.25 or 2.5 mg Hg/kg, alone or in combination with sodium selenite (Se) at a level of 0.5 mg Se/kg. Simultaneously, the level of metallothioneinlike proteins (MTP) and endogenous copper (Cu) was monitored in tissues of control rats and intoxicated rats.Regardless of the dose, the highest concentrations of inorganic mercury from both the alkylmercurials was found in the rat kidneys. Sodium selenite had a variable effect on the amount of inorganic mercury liberated, depending on the organ and the molar ratio of Hg:Se administered.A statistically significant increase in the levels of MTP and endogenous Cu, compared with control group, was found only in the kidneys of intoxicated rats. This increase was dependent on the concentration of inorganic mercury liberated by biotransformation of alkylmercurials. The observed changes appeared when the level of inorganic mercury exceeded 10,Ig Hg/g tissue and reached a plateau at about 40 ,ug Hg/g tissue. In the presence of selenium the plateau of MTP and Cu levels were no oberved in the kidneys, regardless of the amount of inorganic mercury liberated.

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“…2) No studies have dealt with the role of selenite in methylmercury degradation in vivo, but a few experiments have suggested increased degrada tion. 3,4) This study aimed to examine the role of co administered selenite and methylmercury in in organic mercury accumulation by changing the dose of selenite. If selenite is involved in the procedure of C-Hg breakage, the extent of in organic mercury accumulation should be related to its dosage.…”

Section: Accumulationmentioning

confidence: 99%

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Suzuki¹,

YAMAMOTO²

1984

Sangyo Igaku

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Mice were fed methylmercury (10nmol/g feed) and selenite (0,8,20 or 50nmol/ml drinking water) for one or two weeks. Doses of selenite and duration of feeding were determining factors of total mercury and inorganic mercury concentrations in organs.Increasing the dose of selenite produced the following results: concentration of total mercury in creased in the brain and liver and decreased in the blood, kidneys and spleen; concentration of inorganic mercury increased in the liver and spleen, decreased in the kidneys, and remained unchanged in the brain; the rate of inorganic mercury to total mercury increased in the liver and spleen, decreased in the brain, and remained unchanged in the kidneys. In every case, inorganic mercury in the blood was below the detection limit.

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Studies on the mechanism of protective effects of selenium against the toxicity of methylmercury.

Cited by 29 publications

References 0 publications

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite

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