Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka, Elzbieta A.; Chmielnicka, Jadwiga

doi:10.2307/3429989

Cited by 3 publications

(9 citation statements)

References 35 publications

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“…Table 5 shows numerical values of this coefficient calculated from our data. These results indicate that values bDetermined as 203Hg (51,52). cDetermined by AAS according to Balcerska et al (64).…”

Section: Discussionmentioning

confidence: 98%

“…On the other hand, at low selenium concentrations in the kidneys with respect to high concentrations of inorganic mercury, an increase in the concentration of mercury in this organ was observed ( bDetermined as 203Hg (51,52).…”

Section: Discussionmentioning

confidence: 99%

“…The effect of interaction between the alkylmercurials and sodium selenite (depends on the molar Hg:Se ratio) is found to consist of a change of the distribution and therefore of concentrations of total mercury (51,52) and both its forms in individual tissues (Table 2 and 3). However, no significant differences in the percent contribution of inorganic mercury to the total mercury content in the tissues were found between animal groups poisoned with alkymercurials alone and those receiving sodium selenite in addition to mercury (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…It was also demonstrated that Me 03Hg (49,51), methoxyethyl 203Hg (49) and Et203Hg (52) are bound by low molecular weight proteins of the soluble fraction of rat kidneys.…”

Section: Introductionmentioning

confidence: 99%

“…Our previous studies (51,52) have dealt with the metabolism of methyl-and ethylmercuric chloride in rats in the presence and absence of selenium. the present study was designed to determine if there is a relationship between the amount ofinorganic mercury liberated from these alkylmercurial compounds in the presence and absence of selenium and the concentration of metallothionein proteins and endogenous copper in some rat tissues.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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The biotransformation efficiency of alkylmercurial compounds was studied in rat liver, kidneys, blood, and brain after 2-week administration of methylmercuric chloride (MeHg) and ethylmercuric chloride (EtHg) at doses of 0.25 or 2.5 mg Hg/kg, alone or in combination with sodium selenite (Se) at a level of 0.5 mg Se/kg. Simultaneously, the level of metallothioneinlike proteins (MTP) and endogenous copper (Cu) was monitored in tissues of control rats and intoxicated rats.Regardless of the dose, the highest concentrations of inorganic mercury from both the alkylmercurials was found in the rat kidneys. Sodium selenite had a variable effect on the amount of inorganic mercury liberated, depending on the organ and the molar ratio of Hg:Se administered.A statistically significant increase in the levels of MTP and endogenous Cu, compared with control group, was found only in the kidneys of intoxicated rats. This increase was dependent on the concentration of inorganic mercury liberated by biotransformation of alkylmercurials. The observed changes appeared when the level of inorganic mercury exceeded 10,Ig Hg/g tissue and reached a plateau at about 40 ,ug Hg/g tissue. In the presence of selenium the plateau of MTP and Cu levels were no oberved in the kidneys, regardless of the amount of inorganic mercury liberated.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…It was also demonstrated that Me 03Hg (49,51), methoxyethyl 203Hg (49) and Et203Hg (52) are bound by low molecular weight proteins of the soluble fraction of rat kidneys.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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The Hair-Organ Relationship in Mercury Concentration in Contemporary Japanese

Suzuki

Hongo

Yoshinaga

et al. 1993

Archives of Environmental Health: An International Journal

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The hair-organ relationship of mercury concentration was investigated in 46 autopsy samples in Tokyo, Japan. Hair mercury levels were highly significantly correlated with organ Hg levels in the cerebrum, cerebellum, heart, spleen, liver, kidney cortex, and kidney medulla, when the total mercury or methyl mercury value in the organ was compared with the hair total mercury or organic mercury, respectively. When the inorganic mercury value was tested, significant correlations remained, with weaker coefficients in all the organs but the spleen. Stepwise multiple regression analysis evidenced that the hair organic mercury value was the major explanatory variable for the organ total mercury or organ methyl mercury value in all the organs. To explain the organ inorganic mercury value, the hair organic mercury value was the major variable for the cerebrum and kidney (both cortex and medulla), the hair inorganic mercury value was the major variable for the cerebellum and heart, and the hair phosphorous and hair organic mercury were the major variables for the liver; no explanatory variable existed for the spleen. Auxiliary explanatory variables accounted for the organ total mercury and inorganic mercury levels, among which the hair selenium value was conspicuous with negative regression coefficients.

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Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite.

Brzeźnicka¹,

Chmielnicka²

1985

Environ Health Perspect

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The biotransformation efficiency of alkylmercurial compounds was studied in rat liver, kidneys, blood, and brain after 2-week administration of methylmercuric chloride (MeHg) and ethylmercuric chloride (EtHg) at doses of 0.25 or 2.5 mg Hg/kg, alone or in combination with sodium selenite (Se) at a level of 0.5 mg Se/kg. Simultaneously, the level of metallothioneinlike proteins (MTP) and endogenous copper (Cu) was monitored in tissues of control rats and intoxicated rats. Regardless of the dose, the highest concentrations of inorganic mercury from both the alkylmercurials was found in the rat kidneys. Sodium selenite had a variable effect on the amount of inorganic mercury liberated, depending on the organ and the molar ratio of Hg:Se administered. A statistically significant increase in the levels of MTP and endogenous Cu, compared with control group, was found only in the kidneys of intoxicated rats. This increase was dependent on the concentration of inorganic mercury liberated by biotransformation of alkylmercurials. The observed changes appeared when the level of inorganic mercury exceeded 10 micrograms Hg/g tissue and reached a plateau at about 40 micrograms Hg/g tissue. In the presence of selenium the plateau of MTP and Cu levels were no observed in the kidneys, regardless of the amount of inorganic mercury liberated.

show abstract

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Cited by 3 publications

References 35 publications

Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite

Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite

The Hair-Organ Relationship in Mercury Concentration in Contemporary Japanese

Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite.

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