Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals

Kesari, Achyut Narayan; Kesari, Shweta; Singh, Santosh Kumar; Gupta, Rajesh Kumar; Watal, Geeta

doi:10.1016/j.jep.2007.03.023

Cited by 137 publications

(93 citation statements)

References 40 publications

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“…Hence, the present study reconfirms our previous observations about antidiabetic effect by showing improvement in enzymatic assays affected due to hepatic injury caused by STZ induced diabetes. The serum creatinine level of severely treated diabetic rats was also found to decrease on treatment suggesting theirby an improvement in kidney function also in addition to liver function (17).…”

Section: Discussionmentioning

confidence: 90%

Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats

Singh¹,

Kumar

Mehta

et al. 2009

Indian J Clin Biochem

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Section: Discussionmentioning

confidence: 90%

Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats

Singh¹,

Kumar

Mehta

et al. 2009

Indian J Clin Biochem

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“…Serious long-term complications include heart disease, stroke, chronic kidney failure, foot ulcers, and damage to the eyes [2] . A number of investigations, of oral antihyperglycemic agents from plants used in traditional medicine, have been conducted and many of the plants were found with good activity [3] . The World Health…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats

El-Gamal¹

2017

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“…On the other hand, treatment with CcB bark extract significantly reduced blood triglyceride levels in diabetic rats, and did not have effect on blood triglycerides in non-diabetic rats. Other studies suggest that TG itself is independently related to coronary heart disease (2,6) , and most of the anti-hypercholesterolemic drugs do not decrease TG levels (13) , but CcB extract treatment returned the triglycerides to control values. This suggests that CcB bark extract has a hypolipidemic activity, and could be used to reverse dyslipidemia associated with diabetes and to prevent the cardiovascular complications that are very prevalent in diabetic patients.…”

Section: Discussionmentioning

confidence: 93%

Hepatics alterations and genotoxic effects of Croton cajucara Benth (SACACA) in diabetic rats

Rodrigues

Marcolin

Bona

et al. 2010

Arq. Gastroenterol.

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-Context -Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark and leaf infusions of this plant have been popularly used to treat diabetes and hepatic disorders. Objectives -This study investigated effects hepatics alterations and genotoxic and antidiabetic effect of Croton cajucara Benth bark extracts treatment in streptozotocin-induced diabetic rats. Methods -Male Wistar rats were divided into six groups: control rats; control rats treated with Croton cajucara Benth extract during 5 and 20 days; diabetic rats, and diabetic rats treated with Croton cajucara Benth during 5 and 20 days. Diabetes was induced by a single intraperitoneal injection of streptozotocin (70 mg/kg). Eight weeks later we measured glucose, triglyceride, cholesterol and hepatic transaminases on blood. The bone marrow micronucleus assay was used to assess the genotoxic activity of Croton cajucara Benth.Results -Treatment with aqueous extrat of Croton cajucara was able to significantly reduce levels of triglycerides in diabetic animals, however, did not modify significantly the levels of glucose and cholesterol in these animals. There was no significant elevation in liver transaminases in the control group treated with Croton cajucara Benth, as there was no genotoxic effect of treatment in this model. Our results did not show a significant effect on glucose and cholesterol reduction, the treatment was able to significantly reduce triclycerides plasmatic level. There was no significant alterations on hepatic transferase in the animals from the control group treated with Croton cajucara Benth. It was observed no genotoxic effect of the treatment in the model studied. Conclusion -In this study Croton cajucara bark extract showed absence of hepatotoxicity in this animal model and presented a hypolipidemic activity, and could be used to reverse dyslipidemia associated with diabetes and to prevent the cardiovascular complications that are very prevalent in diabetic patients. HEADINGS -Drug-induced liver injury. Diabetes mellitus. Croton, toxicity. Rats.

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Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals

Cited by 137 publications

References 40 publications

Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats

Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats

Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats

Hepatics alterations and genotoxic effects of Croton cajucara Benth (SACACA) in diabetic rats

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