Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats

El-Gamal, El-Khedr Mohamed Mostafa

doi:10.18535/jmscr/v5i2.39

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…DADS has been shown as a protein glycation inhibitor [13] may prevent insulin glycation, thereby enhances the life span of insulin and such an enhancement in group 4 may influence insulin life span, hence may cause increase glucose utilization and lactate production as observed in the present study. The raise in lactate production in group 4 which is in agreement with earlier studies [23] and is due to enhancement of glucose utilization through glycolytic pathway in group 4 as compared to group 2, which is further evidenced by a proportional raise in activity of HK, which is supposed to be a thiol enzyme and the thiols produced by degradation of DADS may influence its activity.…”

Section: Rssr+enzyme-sh → Rsh+enzyme-s-s-rsupporting

confidence: 67%

“…Even the World Health Organization (WHO) has also recommended the evaluation of plants effectiveness in controlling rampant spreading of DM as we lack in safe modern drugs [12]. This has led to increasing demand for research on natural anti-diabetic products which produces minimal or no side effects [13]. Allium group of plants in general and garlic products in particular were proved to have beneficial effects in DM [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Effect of diallyl disulphide on glucose utilization in isolated alloxan diabetic liver

Goudappala¹,

Sukumar²,

Rt³

2018

biomedicalresearch

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The garlic and its principle sulfur compound, diallyl disulphide (DADS) have been claimed to have hypoglycemic action and are beneficial in achieving glycemic control in diabetes mellitus (DM). The actual mechanism how the DADS regulates glucose level in DM is not clearly established though it is known that DADS do influence insulin action probably by improving insulin half-life. A study was undertaken to assess the influence of DADS on glucose utilization in isolated alloxan diabetic liver tissues and to compare DADS action with standard hypoglycemic drug, metformin. The study included four groups: group-1 (normal control liver tissues), group-2 (alloxan diabetic liver tissues), group-3 (Metformin exposed alloxan diabetic liver tissues) and group-4 (DADS exposed alloxan diabetic liver tissues). The liver tissues of groups 3 and 4 were incubated respectively with metformin (4 mg/g liver) and DADS (4 mg/g liver) for one hour at 37°C. The results showed significant raise (p<0.01) in glucose utilization and lactate production in group 4 liver tissues as compared to group 2 suggesting influence of DADS on the glucose utilization promotional effect of DADS which is quite comparable with metformin. The influence of glucose utilization by DADS is through increasing glycolysis in liver as well as its utilization through hexose mono phosphate (HMP) pathway as suggested by increased hexokinase (HK) and glucose-6-phosphate dehydrogenase (G6PD) activities. Study signifies the use of DADS as adjuvant therapy for glycemic control in DM.

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Section: Rssr+enzyme-sh → Rsh+enzyme-s-s-rsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%