Studies on the effect of metal ions of hydrazone complexes on interaction with nucleic acids, bovine serum albumin and antioxidant properties

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

“…The overall order of interaction between the ligands/complexes and CT DNA as well as BSA decreased in the order 6 > 5 > 4 > 3 > 2 > 1. The results of the studies are compared with similar metal complexes reported earlier 52,53 and are listed in Table 4.…”

“…From the above values (Table 5), it is found that all the metal complexes tested in this study behaved as more effective inhibitors than the standard scavenging agent, butylated hydroxy anisole (BHA) for O 2 − , OH and NO radicals and are compared with that of the other nickel complexes. 53,62 In general, the antioxidant activity of synthesised compounds against the free radicals O 2 − , OH and NO decreased in the order 6 > 5 > 4 > 3 > 2 > 1. Among all three nickel hydrazones, the one possessing six membered pyridine ring in the hydrazone moiety (complex 6) showed more potential scavenging activity than the rest of the complexes with five membered furan and thiophene rings in the complexes 4 and 5.…”

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

“…Hydrazones are an emerging class of materials, which have been demonstrated to possess awide range of biological and pharmaceutical activities such as antimicrobial, anti-convulsant, antifungal,anticancer, antitubercular, antiviral,antibacterial, and antioxidant activities [1][2][3][4][5][6][7][8].M eanwhile,h ydrazones have also interesting properties because of the presence of several coordinations ites,a nd thus theirm etal complexes are important for their possible biological applications [9].T he thiazole ring is present in various biologically active molecules. Thiazoles and their derivatives possessa ctivities such as antitumor, antiviral, and antibacterial [10][11][12].…”

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

“…Hydrazones are an emerging class of materials, which have been demonstrated to possess a wide range of biological and pharmaceutical activities such as antimicrobial [1], anti-convulsant [2], antifungal [3], anticancer [4], antitubercular [5], antiviral [6], antibacterial [7], and antioxidant [8] activities. Meanwhile, hydrazones have also interesting properties because of the presence of several coordination sites, and thus their metal complexes are important for their possible biological applications [9].…”