Studies on the Constituents of Callicarpa Formosana Rolfe

Abstract

Two new naturally occurring flavonoids, 3,4′,5,7‐tetramethoxyflavone and 3,3′,4′,5,7‐pentamethoxyflavone, along with known compounds, 5‐hydroxy‐3,4′,7‐trimethoxyflavone, 5‐hydroxy‐3,3′,4,7‐tetramethoxyflavone, ursolic acid, 2α,3α‐dihydroxyurs‐12‐en‐28‐oic acid, phytosterols, and phytosteryl glucosides, have been isolated and characterized from the fresh leaves of Callicarpa formosana Rolfe.

Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata

“…The fractions with muscarinic receptor binding activities were separated further to obtain pure compounds. The compounds characterized by NMR and MS were six polymethoxyflavones [3,5,6,7,8-pentamethoxy-3 0 ,4 0 -methylenedioxyflavone (1) (Fauvel et al, 1981;Jong and Wu, 1989;Ritchie et al, 1965); 3,5,6,7-tetramethoxy-3 0 ,4 0 -methylenedioxyflavone (3) (Jong and Wu, 1989;Ritchie et al, 1965); 3,3 0 ,4 0 ,5,7-pentamethoxyflavone (4) (Chen et al, 1986;de la Torre et al, 2004;Dong et al, 1999;Herunsalee et al, 1987); 3,5-dimethoxy-3 0 ,4 0 ,6,7-bismethylenedioxyflavone (5) (Fauvel et al, 1981;Higa et al, 1987;Jong and Wu, 1989;Ritchie et al, 1965); 3,5,8-trimethoxy-3 0 ,4 0 ,6,7-bismethylenedioxyflavone (6) (Fauvel et al, 1981;Higa et al, 1987;Jong and Wu, 1989); and 3,5,7-trimethoxy-3 0 ,4 0 -methylenedioxyflavone (7) (Higa et al, 1987;Ho et al, 2003)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2) (Franke et al, 2001;Sokolova et al, 1976)]. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata.…”

Neo-Clerodane Diterpenoids from Verbenaceae: Structural Elucidation and Biological Activity

“…Also, alterative and febrifugal properties [57], and ecbolic, hypertensive and laxative effects [58] were quoted for C. inerme. Callicarpa plants are used for the treatment of rheumatism, stomach disorders and intestinal troubles [59], and piscicidal components have been studied [31,60]. The Malaysian species Callicarpa pentandra, as a liquid, is drunk for colds [61] and preparations of the bark of C. americana have been used to treat fever [62], the leaves to treat dropsy [63], and the roots to alleviate colic [64], dysentery [65] and skin cancer [66], whereas preparations of the roots and branches have been taken to relieve malaria, rheumatism and fever [64].…”

Anticancer activity of Callicarpa arborea Roxb. extracts against Type-II human lung adenocarcinoma cell line, A549

“…(Beautyberry) locally called as 'Hnahkiah' is a small evergreen tree belongs to family Verbanaceae and is widely distributed in the Asia-Pacific regions (Shihan et al, 2015). The leaves and bark of C. arborea have been extensively used for the treatment of inflammation (Mi et al, 1984), diabetes (Junejo et al, 2017) and intestinal disorder (Chen et al, 1986). The local people of Mizoram use the leaves and bark of C. arborea as haemostatic agent and for the treatment of abdominal colic (Sharma et al, 2016) as well as in cancer treatment (Lalfakzuala, 2007).…”