Studies on the biosynthesis of blood pigments. 1. Haem synthesis in haemolysed erythrocytes of chicken blood

Lipoperoxidative Damage on Lead Exposure in Rat Brain and its Implications on Membrane Bound Enzymes

“…The decrease in catalase activity, observed in the study may be attributed to the reduced absorption of iron or due to the inhibition of haem biosynthesis, as lead has been shown to interfere with both processes (Dresel & Falk 1954). The decrease in catalase activity, observed in the study may be attributed to the reduced absorption of iron or due to the inhibition of haem biosynthesis, as lead has been shown to interfere with both processes (Dresel & Falk 1954).…”

Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver

“…CAT is a major antioxidant enzyme having heme as the prosthetic group. Lead is known to reduce the absorption of iron in the gastrointestinal tract and to inhibit the heme biosynthesis [57]. Decreased CAT activity observed in lead exposed animals was attributed to the interference of lead by both processes [58].…”

Inactivation of cytochrome P‐450 and production of N‐alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines

“…Incubation was at 37°C and pH 7.4 with gentle rotation [21] (58 cycles/min, the di-'rection being inverted every minute). Haematin, in some experiments prelabelled from 5-amino-[5-14C]laevulinate [22], was added as methaemalbumin [23]. Viability (Trypan blue exclusion) declined from 95-87% to 85-75s after incubation.…”