Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver

Sivaprasad, R.; Nagaraj, M.; Varalakshmi, P.

doi:10.1016/j.jnutbio.2003.09.001

Cited by 110 publications

(80 citation statements)

References 60 publications

(60 reference statements)

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“…Although lead is one of the most useful metal, it is also one of the most toxic metals, producing severe organ damage in animals and humans (Humphreys, 1991;Spivey, 2007;Téllez-Rojo et al, 2004). Several studies have reported that lead toxicity is associated with impaired functioning of brain, liver, kidney, testes and the hematopoietic system (Bellinger, 2008;El-Nekeety et al, 2009;Sivaprasad et al, 2004). Prolonged exposure to low level of environmental lead has been proved as a risk factor for neurological, cardiovascular and reproductive disorders.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

et al. 2010

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-Lead is known to disrupt the biological systems by altering the molecular interactions, cell signaling, and cellular function. Exposure to even low levels of lead may have potential hazardous effects on brain, liver, kidneys and testes. The efficacy of Etlingera elatior (torch ginger) to protect hepatotoxicity induced by lead acetate was evaluated experimentally in male Sprague -Dawley rats. Rats were exposed to lead acetate in drinking water (500 ppm) for 21 days and the effects of concurrent treatment with extract of E. elatior on hepatic lipid hydroperoxides (LPO), protein carbonyl content (PCC), total antioxidants (TA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione STransferase (GST) levels and histopathological changes in liver were evaluated. There was a significant decrease in TA and other antioxidant enzymes (p < 0.05) and increase in LPO and PCC (p < 0.05) with lead acetate ingestion. Concurrent treatment with E. elatior extract significantly reduced the LPO and PCC (p < 0.05) in serum and increased the antioxidant enzyme levels (p < 0.05) in the liver. Significant histopathological changes were seen in hepatic tissue with chronic lead ingestion. Treatment with E. elatior significantly reduced these lead-induced changes in hepatic architecture. E. elatior has also reduced the blood lead levels (BLL). Thus, there has been extensive biochemical and structural alterations indicative of liver toxicity with exposure to lead and E. elatior treatment significantly reduced these oxidative damage. Our results suggest that E. elatior has a powerful antioxidant effect against lead-induced hepatotoxicity.

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Section: Introductionmentioning

confidence: 99%

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

et al. 2010

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“…In addition, lead interferes with DNA repair mechanisms that normally take place to preserve DNA integrity, thereby increasing DNA fragmentation further. Several studies showed that DNA damage can be induced by reactive oxygen species (ROS) produced during lipid peroxidation (LPO), [7,16,10] one of the manifestations of oxidative damage which occurs readily in the tissues due to the presence of membrane rich polyunsaturated highly oxidizable fatty acids. It was found that LPO induced by lead alters physiological and biochemical characteristics of biological systems [49].…”

Section: Discussionmentioning

confidence: 99%

“…Lead is known to cause histological liver damage and possibly disturb the normal biochemical process, resulting in increased liver enzyme levels. Mechanisms of lead-induced liver injury include increased production of reactive oxygen species (ROS), and induced oxidative stress which results in DNA damage [6][7][8][9][10][11][12]. DNA alteration may occur either via caspase 3 activation or oxidative stress by generating the release of reactive oxygen species (ROS) such as superoxide radicals, hydrogen peroxide and hydroxyl radicals and lipid peroxydation [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Hepatotoxic Effects of Lead Acetate in Rats: Histopathological and Cytotoxic Studies

Zidi¹

2014

J Cytol Histol

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Lead toxicity is probably the most common form of heavy metal intoxication. The present study was conducted to assess the histopathological and cytotoxic effects of lead exposure on rat liver.Adult male Wistar rats were randomly divided in 2 groups. The first was exposed to 2 g of lead acetate in distilled water during 35 days, while the second served as a control group and was given distilled water. The structural damage in the liver was investigated by histological study and supplemented by biochemical assay of liver enzyme levels. DNA fragmentation in somatic cells was determined using terminal desoxynucleotidyl transferase mediated dUTP nick end-labeling (TUNEL) assay.The results obtained show increase in liver enzyme levels in treated rats compared to controls. The histological study showed that lead can induce several alterations such as hypertrophy of hepatocytes, portal space and central vein dilatation, vacuolation and lymphocytic infiltration. Tunel assay revealed significant DNA fragmentation in rats exposed to lead. This study showed that TUNEL assay can be used to determinate DNA fragmentation in somatic cells of rat liver. Moreover, we conclude that lead acetate may be considered as a strong hepatotoxic and genotoxic agent.

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“…Liver plays a major role in lead metabolism and it is therefore in special risk due to its oxidative action, given the unquestionable evidences that lead-induced lipid peroxidation of cellular membranes play a crucial role in the mechanism of hepatotocellular damage (Sivaprasad et al, 2004). The biochemical alterations occur prior to morphological changes in the organs, and the changes in certain enzyme levels in extracellular fluids may reflect the extent of Pbinduced damage in target organs (Patra et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Ismail¹,

Taha²,

Mandour³

et al. 2017

AJVS

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Key words:Quails; Lead; Lipoic acid; Antioxidant; Malondialdehyde, Copper Quails are exposed to deleterious doses of lead from different sources which decrease the bird performance, and growth with economic loses. This work aimed to explore the antioxidative effect of alpha lipoic acid to counteract the adverse effects of lead in Japanese quails. Forty Japanese quails with both sex were grouped into control, lead acetate (100 ppm in drinking water), alpha lipoic acid (1 g/kg diet), and the final group which received both lipoic acid and lead acetate of the same doses. Lead acetate significantly increased the liver enzymatic biomarkers (ALT, AST, and ALP), and bilirubin levels with decline in the serum total protein and albumin concentrations. Also, lead, copper concentrations in liver tissue were significantly increased with decreased hepatic iron level and serum calcium and phosphorus levels following lead acetate administration. Moreover, lead significantly increased hepatic malondialdehyde level with attenuation of antioxidant enzymes; GPX, GST, CAT, and SOD activities and nonenzymatic antioxidant; GSH concentration. Co-administration of alpha-lipoic acid together with lead acetate significantly improved the liver functions, increased the antioxidant activities, and corrected the serum and hepatic major and trace element concentrations without any effect on hepatic lead level. Our results suggested that alpha lipoic acid can counteract the deleterious effects of lead in quails through attenuation of oxidative stress and enhancement of antioxidative capacity in liver tissues.Correspondence to:

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Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver

Cited by 110 publications

References 60 publications

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

Hepatotoxic Effects of Lead Acetate in Rats: Histopathological and Cytotoxic Studies

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

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