Studies on Serum Total Cholesterol, in Second and Third Trimester of Pregnancy

Husain, F; Latif, SA; Uddin, MM

doi:10.3329/jbsp.v1i0.712

Cited by 6 publications

(9 citation statements)

References 11 publications

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“…Our results are in accord with previous studies that have shown that blood lipid concentrations increase during pregnancy, with cholesterol concentrations estimated to increase by up to 70% compared to pre-pregnancy concentrations [ 3 , 16 , 22 – 24 ]. Compared to non-pregnant women, triglyceride concentrations in late pregnancy may be up to 138% higher [ 3 ].…”

Section: Discussionsupporting

confidence: 93%

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Geraghty

Alberdi

O’Sullivan

et al. 2017

BMC Pregnancy Childbirth

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BackgroundPregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations have been associated with adverse pregnancy outcomes such as gestational diabetes, pregnancy-induced hypertension and high birth weight. As blood lipids are not routinely measured during pregnancy, there is limited information on what is considered normal during pregnancy and in fetal blood.MethodsData from 327 mother-child pairs from the ROLO longitudinal birth cohort study were analysed. Fasting total cholesterol and triglycerides were measured in early and late pregnancy and fetal cord blood. Intervals were calculated using the 2.5th, 50th and 97.5th centile. Data was stratified based on maternal body mass index (BMI) measured during early pregnancy. Differences in blood lipids between BMI categories were explored using ANOVA and infant outcomes of macrosomia and large-for-gestational-age (LGA) were explored using independent student T-tests and binary logistic regression.ResultsAll maternal blood lipid concentrations increased significantly from early to late pregnancy. In early pregnancy, women with a BMI < 25 kg/m2 had lower concentrations of total cholesterol compared to women with a BMI of 25–29.9 kg/m2 (P = 0.02). With triglycerides, women in the obese category (BMI > 30 kg/m2) had higher concentrations than both women in the normal-weight and overweight category in early and late pregnancy (P < 0.001 and P = 0.03, respectively). In late pregnancy, triglyceride concentrations remained elevated in women in the obese category compared to women in the normal-weight category (P = 0.01). Triglyceride concentrations were also elevated in late pregnancy in mothers that then gave birth to infants with macrosomia and LGA (P = 0.01 and P = 0.03, respectively).ConclusionBlood lipid concentrations increase during pregnancy and differ by maternal BMI. These intervals could help to inform the development of references for blood lipid concentrations during pregnancy.Trial registrationROLO Study - ISRCTN54392969. Date of registration: 22/04/2009.

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Section: Discussionsupporting

confidence: 93%

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Geraghty

Alberdi

O’Sullivan

et al. 2017

BMC Pregnancy Childbirth

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“…The present data indicate that blood lipid concentrations also increase in line with this. The increase in serum lipids during pregnancy has been shown in previous research [10–13] with one group of researchers finding that a mother’s serum cholesterol concentrations rise by approximately 50–70% during pregnancy compared to normal concentrations [27]. Others have reported that, compared to non-pregnant women, estimated total cholesterol concentrations increase up to 39% in late pregnancy and triglyceride concentrations may be anywhere up to 138% higher than non-pregnant concentrations in late pregnancy [12].…”

Section: Discussionmentioning

confidence: 91%

Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study

et al. 2016

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BackgroundThe in-utero environment affects fetal development; it is vital to understand how maternal diet during pregnancy influences childhood body composition. While research indicates that triglycerides in hyperglycaemic women may increase birth weight, little is known about this relationship in euglycemic women. This study examines the relationship between maternal blood lipid status and infant adiposity up to 2 years of age.MethodsData from 331 mother-child pairs from the ROLO longitudinal birth cohort study was analysed. Maternal dietary intakes were recorded and fasting blood lipids, leptin and HOMA were measured in early and late pregnancy and cord blood. Infant anthropometric measurements and skin-fold thicknesses were recorded at birth, 6 months and 2 years. Correlation and regression analyses were used to explore associations between maternal blood lipid status and infant adiposity.ResultsAll maternal blood lipids increased significantly during pregnancy. Maternal dietary fat intake was positively associated with total cholesterol levels in early pregnancy. Late pregnancy triglycerides were positively associated with birth weight (P = 0.03) while cord blood triglycerides were negatively associated with birth weight (P = 0.01). Cord HDL-C was negatively associated with infant weight at 6 months (P = 0.005). No other maternal blood lipids were associated with infant weight or adiposity up to 2 years of age.ConclusionMaternal and fetal triglycerides were associated with birth weight and cord HDL-C with weight at 6 months. Thus, maternal lipid concentrations may exert in-utero influences on infant body composition. There may be potential to modulate infant body composition through alteration of maternal diet during pregnancy.

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“…Husain y cols (26), estudian los cambios del perfil lipídico en gestantes del segundo trimestre y describen aumentos significativos de CT, TG y c-LDL, con un ligero aumento aunque estadística-mente no significativo, del c-HDL, hallazgo que coinciden con los datos de este trabajo; pero luego, en otro estudio realizado en el mismo periodo, esta vez estudiando a gestantes del segundo y tercer trimestre, indican que el c-HDL aumenta significativamente junto con los TG, no explicando cual sería la razón para sus hallazgos tan discordantes (27).…”

Section: Discussionunclassified

“…Al comparar el perfil lipídico de un grupo control de mujeres no embarazadas con gestantes del primer trimestre, no se hallaron cambios significativos en los valores de CT (156,88 mg/dl y 159,87 mg/dl para cada grupo, respectivamente) y TG (85,57 mg/ dl y 89,94 mg/dl, respectivamente), contrariamente a lo referenciado por otros autores (27), que indican un aumento significativo de ambos parámetros al comparar los mismos grupos. Numerosos estudios hablan que durante el segundo trimestre del embarazo comienza a observarse un importante aumento en la concentración de CT y de TG, debido a que en los dos primeros trimestres se produce un aumento de depósito de grasa en tejido adiposo, consecuencia de un aumento en la lipogénesis (1)(2)(3)(4)(5)(6)(7)10).…”

Section: Discussionunclassified

Perfil Lipídico Por Trimestre De Gestación en Una Población De Mujeres Adultas

Benítez

Bonneau

Rascón³

et al. 2010

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: En el embarazo se producen variaciones hormonales muy marcadas y estas se asocian con grandes modificaciones del perfil lipídico. Objetivos: Evaluar el perfil lipídico de mujeres adultas por trimestre de gestación y comparar el perfil lipídico de un grupo control de mujeres no embarazadas con gestantes del primer trimestre, que consultan al servicio de Maternidad del Hospital Público Provincial "Dr. Ramón Madariaga". Método: Se estudiaron 248 embarazadas, 69 en primer trimestre, 78 segundo y 101 tercero. Además un grupo control de 43 no gestantes con distribución etárea, índice de masa corporal y criterios de exclusión similares al grupo de gestantes. Se extrajo sangre con 12 horas de ayuno para las determinaciones bioquímicas, las cuales fueron realizadas por métodos enzimáticos colorimétricos, con controles de calidad interno y externo. Resultados: Se encontró que colesterol total, triglicéridos, col-VLDL, col-LDL, los índices colesterol total/col-HDL y triglicéridos/col-HDL, fueron aumentando significativamente en cada trimestre, mientras que el c-HDL no presentó diferencias. Los valores de percentilo 95 del tercer trimestre para CT de 321 mg/dl y TG 371 mg/dl, podrían ser utilizados como valores de corte en nuestra población. Cuando se comparó mujeres no gestantes versus embarazadas del primer trimestre no se encontraron cambios significativos. Conclusiones: El seguimiento del perfil lipídico de las gestantes podría convertirse en una herramienta diagnóstica que permita monitorear aumentos que superen lo considerado como fisiológico, llevando a un adecuado control prenatal. PALABRAS CLAVE: Riesgo aterogénico, embarazo, perfil lipídico SUMMARY Background:In pregnancy hormonal changes occur very marked and these are associated with major changes in the lipid profile. Aims: To evaluate the lipid profile of adult women during normal pregnancy in the first, second and third trimester and to compare the lipid profile of woman who are not pregnant with the lipid profile of woman who are in the first trimester of gestation and who are attended at the Maternity Public and Provincial Hospital "Dr. Ramón Madariaga". Methods: 248 pregnant women were evaluated of which: 69 women were in the first trimester; 78 women were in the second trimester and 101 women were in the third trimester. In addition a control group of 43 non-pregnant women with age distribution, body mass index and exclusion criteria similar to the group of pregnant women. Blood was extracted after twelve hours fasting to get the biochemical determinations which results were gotten by enzymatic colorimetric methods, with internal and external quality control. Results: It was found that total cholesterol; triglycerides, very low density and low density lipoprotein, the total cholesterol index/ high density lipoprotein y triglycerides/ high

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Studies on Serum Total Cholesterol, in Second and Third Trimester of Pregnancy

Cited by 6 publications

References 11 publications

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study

Perfil Lipídico Por Trimestre De Gestación en Una Población De Mujeres Adultas

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