Studies on Frost-Bite With Special Reference to Treatment and the Effect on Minute Blood Vessels

Quintanilla, Ramon; Krusen, Frank H.; Essex, Hiram E.

doi:10.1152/ajplegacy.1947.149.1.149

Cited by 70 publications

(17 citation statements)

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“…Gangrene does not occur without actual freezing if the period of exposure is as brief as one hour. The recent experiments of Quintanilla et al (10), who were also unable to demonstrate the effectiveness of heparin in the treatment of frostbite of rabbit feet, illustrate the variability in the severity of injury in this temperature range.…”

Section: Discussionmentioning

confidence: 96%

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Studies on Gangrene Following Cold Injury. Ix. The Effect of Rutin and Other Chemical Agents on the Course of Experimental Frostbite in Rabbits 12

Fuhrman¹,

Crismon²

1948

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 96%

“…Recently Lange and Boyd (9) reported that tissue loss following experimental frostbite was reduced by treatment with heparin intravenously, but Quintanilla, Krusen and Essex (10) to reduce the extent of tissue loss following frostbite of rabbit feet; the major part of this report is therefore devoted to this substance.…”

mentioning

confidence: 96%

Studies on Gangrene Following Cold Injury. Ix. The Effect of Rutin and Other Chemical Agents on the Course of Experimental Frostbite in Rabbits 12

Fuhrman¹,

Crismon²

1948

J. Clin. Invest.

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“…Also there have been many studies on frostbitten tissue experimentally about the physiopathogenesis of frostbite [2]. It is revealed that frostbite injury causes direct cellular damage and death and the second one is progressive tissue ischemia [3][4][5][6][7][8][9]. Acute effects of frostbite can be seen as formation of extracellular ice crystals.…”

Section: Discussionmentioning

confidence: 99%

The current analysis of the effect of hyperbaric oxygen therapy on the frostbitten tissue: Experimental study in rabbits

et al. 2009

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AbstractMany experimental studies have been performed and the mechanism of hyperbaric oxygen therapy on the frostbitten tissue has not been elucidated. In this study, we evaluated the effect of hyperbaric oxygen therapy on the frostbitten ears of rabbits in an experimental animal model by examining the concentrations of thromboxane A2 (as thromboxane B2-Tx B2) and of prostaglandin I2 (PG I2) (as 6-keto-prostaglandin F1α-PG F1α) in tissues, and by counting the numbers of inflammatory cells (neutrophils and mast cells-MC) Hyperbaric oxygen therapy (HBO) at 2.5 ATA for 90 minutes twice daily for fourteen days to rabbits, the ears of which were subjected to frostbite, decreased presence of inflammatory cells (mast cells −75%; neutrophils −40%) and increased prostaglandin I2 (PG I2) (as 6-Keto-PGF1α) in the involved skin. Thromboxane A2 (TxA2) (as Tx B2) was unaffected. Our results revealed that an inflammatory process was the underlying cause of frostbite injury and that hyperbaric oxygen therapy was active in pathological situations involving an inflammatory process in frostbite.

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“…Thus the effects of freezing may result in damage to the red blood cells, causing deformation and lysis, or direct endothelial cell damage to the vessel walls, increasing macromolecular leakage and haemoconcentration. Classical clotting mechanisms have previously been excluded as a mechanism by which vessel diameters alter and blood flow ceases, since cessation of blood flow is still observed after freezing in the presence of heparin (Quintanilla et al, 1947). Histamine and 5-HT released from mast cells and causing either constriction or dilation have been suggested as possible mediators affecting blood flow, although as yet there is no experimental evidence that freezing triggers the release of such factors.…”

Section: Discussionmentioning

confidence: 99%

The effect of cryotherapy on the cremaster muscle microcirculation in vivo

Brown

Pollock²,

Bayjoo³

et al. 1994

Br J Cancer

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Summary The effect of cryotherapy on normal striated muscle was investigated using 18 adult male rats. Animals were divided into two groups, an experimental cryotherapy group and a control group receiving sham treatment. After the surgical procedure animals were allowed to equilibrate and vessel diameters, macromolecular leakage and blood flow were assessed before the cremaster muscle was frozen to -60°C. After thawing measurements were taken every 15 min over a 2 h period. Cryotherapy resulted in an initial reduction in blood flow followed by a brief period of reperfusion, with complete vascular stasis eventually observed. Macromolecular leakage occurred from all vessels, which mirrored the fluctuations in blood flow. Transient changes in vessel diameters were also observed. Histology confirmed the in vivo observations of vessel congestion and muscle damage. The data suggest that cessation of flow and increased macromolecular leakage within the muscle may contribute to the cell death and tumour necrosis observed following cryotherapy.

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Studies on Frost-Bite With Special Reference to Treatment and the Effect on Minute Blood Vessels

Cited by 70 publications

References 0 publications

Studies on Gangrene Following Cold Injury. Ix. The Effect of Rutin and Other Chemical Agents on the Course of Experimental Frostbite in Rabbits 12

Studies on Gangrene Following Cold Injury. Ix. The Effect of Rutin and Other Chemical Agents on the Course of Experimental Frostbite in Rabbits 12

The current analysis of the effect of hyperbaric oxygen therapy on the frostbitten tissue: Experimental study in rabbits

The effect of cryotherapy on the cremaster muscle microcirculation in vivo

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