Studies on fish scale formation and resorption—II. Effect of estradiol on calcium homeostasis and skeletal tissue resorption in the goldfish, Carassius auratus, and the killifish, Fundulus heteroclitus

Mugiya, Yasuo; Watabe, Norimitsu

doi:10.1016/0300-9629(77)90455-8

Cited by 138 publications

(85 citation statements)

References 19 publications

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“…This increase in calcium demand during the reproductive period in freshwater fish is met not only from external sources but also by mobilisation of internal calcium stores, such as bone and scales which, in tilapia, account for up to 95% of the total body calcium (Flik et al 1986). In goldfish, killifish (Mugiya & Watabe 1977) and rainbow trout (Carragher & Sumpter 1991, Persson et al 1994, bone is initially spared and calcium mobilisation takes place predominantly from the scales. Moreover, in juvenile rainbow trout the effect of oestrogen at the level of the scales appears to be via high-affinity, low-capacity E 2 -binding sites (Persson et al 2000) and oestrogen receptor mRNA is expressed in this tissue (Armour et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Guerreiro

Fuentes

Canário³

et al. 2002

Journal of Endocrinology

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In all teleost fishes vitellogenesis is triggered and maintained by oestradiol-17 (E 2 ) and is accompanied by an increase of blood plasma calcium and phosphate. The action of this hormone on calcium metabolism was investigated by treating fast-growing immature juvenile sea bream (Sparus aurata) with coconut butter implants alone (control) or implants containing 10 µg/g E 2 . Treatment with E 2 induced the production of circulating vitellogenin, a 2·5-fold increase in plasma ionic Ca 2+ and a 10-fold increase in plasma total calcium, largely bound to protein.In contrast to freshwater species, which obtain most of their calcium from the environment directly through the gills, the intestinal component of calcium uptake of the salt water-living sea bream represented up to 60-70% of the total uptake. The whole body calcium uptake, expressed as the sum of calcium obtained via intestinal and extra-intestinal (likely branchial) routes increased significantly in response to E 2 . Combined influx and unchanged efflux rates resulted in a significant 31% increase in net calcium uptake. There was no evidence for an effect of E 2 on the calcium and phosphate content of the scales or the tartrate-resistant acid phosphatase activity (an index for bone/scale osteoclast activity). While most freshwater fish appear to rely on internal stores of calcium, i.e. bone and/or scales to increase calcium availability, the marine sea bream accommodates calcium-transporting mechanisms to obtain calcium from the environment and preserve internal stores. These observations suggest that a fundamental difference may exist in the E 2 -dependent calcium regulation between freshwater and marine teleosts.

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Section: Introductionmentioning

confidence: 99%

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Guerreiro

Fuentes

Canário³

et al. 2002

Journal of Endocrinology

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“…There is ample evidence that scale resorption increases during sexual maturation of several salmonid species (Crichton, 1935;Järvi and Menzies, 1936;van Someren, 1937;Takagi, 1990;Persson et al, 1998) and that E 2 treatment induces calcium mobilization from scales in goldfish (Carassius auratus), killifish (Fundulus heteroclitus), and rainbow trout (Oncorhynchus mykiss) (Mugiya and Watabe, 1977;Carragher and Sumpter, 1991;Persson et al, 1994). The E 2 -induced calcium mobilization from rainbow trout scales is due to an increased scale osteoclast activity (Persson et al, 1995, and an increased scale osteoclast activity has been observed during sexual maturation of Atlantic salmon, Salmo salar (Persson et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

The Presence of High-Affinity, Low-Capacity Estradiol-17β Binding in Rainbow Trout Scale Indicates a Possible Endocrine Route for the Regulation of Scale Resorption

Persson

Shrimpton

McCormick³

et al. 2000

General and Comparative Endocrinology

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High-affinity, low-capacity estradiol-17␤ (Etestosterone, but not by diethylstilbestrol. Hence, the ligand binding specificity is different from that of the previously characterized liver E 2 receptor, where E 2 is displaced by diethylstilbestrol, but not by testosterone. The putative scale E 2 receptor thus appears to bind both E 2 and testosterone, and it is proposed that the increased scale resorption observed during sexual maturation in both sexes of several salmonid species may be mediated by this receptor. No high-affinity, low-capacity E 2 binding could be detected in rainbow trout gill or skin.

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“…The scales are a functional internal calcium reservoir during periods of increased calcium demand, such as sexual maturation and starvation [5,[7][8][9][10][11]. In the scale, as in mammalian bone, type I collagen [12], bone -carboxyglutamic acid protein [13], osteonectin [14,15], and hydroxyapatite [16] are present.…”

Section: Introductionmentioning

confidence: 99%

Parathyroid hormone 1 (1–34) acts on the scales and involves calcium metabolism in goldfish

Suzuki

Danks

Maruyama

et al. 2011

Bone

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The effect of fugu parathyroid hormone 1 (fugu PTH1) on osteoblasts and osteoclasts in teleosts was examined with an assay system using teleost scale and the following markers: alkaline phosphatase (ALP) for osteoblasts and tartrate-resistant acid phosphatase (TRAP) for osteoclasts. Synthetic fugu PTH1 (1-34) (100 pg/ml to 10 ng/ml) significantly increased ALP activity at 6 h of incubation. High-dose (10 ng/ml) fugu PTH1 significantly increased ALP activity even after 18 h of incubation. In the case of TRAP activity, fugu PTH1 did not change at 6 h of incubation, but fugu PTH1 (100 pg/ml to 10 ng/ml) significantly increased TRAP activity at 18 h. Similar results were obtained for human PTH (1-34), but there was an even greater response with fugu PTH1 than with human PTH. In vitro, we demonstrated that both the receptor activator of the NF-B ligand in osteoblasts and the receptor activator NF-B mRNA expression in osteoclasts increased significantly by fugu PTH1 treatment. In an in vivo experiment, fugu PTH1 induced hypercalcemia resulted from the increase of both osteoblastic and osteoclastic activities in the scale as well as the decrease of scale calcium contents after fugu PTH1 injection. In addition, an in vitro experiment with intramuscular autotransplanted scale indicated that the ratio of multinucleated osteoclasts/mononucleated osteoclasts in PTH-treated scales was significantly higher than that in the control scales. Thus, we concluded that PTH acts on osteoblasts and osteoclasts in the scales and regulates calcium metabolism in goldfish.3

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Studies on fish scale formation and resorption—II. Effect of estradiol on calcium homeostasis and skeletal tissue resorption in the goldfish, Carassius auratus, and the killifish, Fundulus heteroclitus

Cited by 138 publications

References 19 publications

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

The Presence of High-Affinity, Low-Capacity Estradiol-17β Binding in Rainbow Trout Scale Indicates a Possible Endocrine Route for the Regulation of Scale Resorption

Parathyroid hormone 1 (1–34) acts on the scales and involves calcium metabolism in goldfish

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