The Presence of High-Affinity, Low-Capacity Estradiol-17β Binding in Rainbow Trout Scale Indicates a Possible Endocrine Route for the Regulation of Scale Resorption

Persson, Petra; Shrimpton, J. Mark; McCormick, Stephen D.; Björnsson, Björn Thrándur

doi:10.1006/gcen.2000.7536

Cited by 32 publications

(32 citation statements)

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“…The hypothesis of a direct effect of oestrogen on bone and/or scale remodelling in salmonids is supported by detection of oestrogen receptor (ER ) mRNA expression in these tissues in the trout (Armour et al 1997). Also, Persson et al (2000) recently characterised a high-affinity, low-capacity binding of E 2 to trout scales. In the sea bream, ER mRNA is not detected in bone and ER is expressed at low levels (only detectable by RT-PCR; Socorro et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…In goldfish, killifish (Mugiya & Watabe 1977) and rainbow trout (Carragher & Sumpter 1991, Persson et al 1994, bone is initially spared and calcium mobilisation takes place predominantly from the scales. Moreover, in juvenile rainbow trout the effect of oestrogen at the level of the scales appears to be via high-affinity, low-capacity E 2 -binding sites (Persson et al 2000) and oestrogen receptor mRNA is expressed in this tissue (Armour et al 1997).…”

Section: Introductionmentioning

confidence: 99%

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Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Guerreiro

Fuentes

Canário³

et al. 2002

Journal of Endocrinology

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In all teleost fishes vitellogenesis is triggered and maintained by oestradiol-17 (E 2 ) and is accompanied by an increase of blood plasma calcium and phosphate. The action of this hormone on calcium metabolism was investigated by treating fast-growing immature juvenile sea bream (Sparus aurata) with coconut butter implants alone (control) or implants containing 10 µg/g E 2 . Treatment with E 2 induced the production of circulating vitellogenin, a 2·5-fold increase in plasma ionic Ca 2+ and a 10-fold increase in plasma total calcium, largely bound to protein.In contrast to freshwater species, which obtain most of their calcium from the environment directly through the gills, the intestinal component of calcium uptake of the salt water-living sea bream represented up to 60-70% of the total uptake. The whole body calcium uptake, expressed as the sum of calcium obtained via intestinal and extra-intestinal (likely branchial) routes increased significantly in response to E 2 . Combined influx and unchanged efflux rates resulted in a significant 31% increase in net calcium uptake. There was no evidence for an effect of E 2 on the calcium and phosphate content of the scales or the tartrate-resistant acid phosphatase activity (an index for bone/scale osteoclast activity). While most freshwater fish appear to rely on internal stores of calcium, i.e. bone and/or scales to increase calcium availability, the marine sea bream accommodates calcium-transporting mechanisms to obtain calcium from the environment and preserve internal stores. These observations suggest that a fundamental difference may exist in the E 2 -dependent calcium regulation between freshwater and marine teleosts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Guerreiro

Fuentes

Canário³

et al. 2002

Journal of Endocrinology

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“…Yamada et al (2002) found that during sexual maturation in female Japanese eels, the calcium and phosphorus contents of the skin (which contains the few scales) remained unchanged, while they decreased in the vertebral skeleton, which constitutes the principal source for calcium and phosphorus. Estrogen receptors were reported in bone and scales of rainbow trout (Armour et al 1997, Persson et al 2000, regenerating scales of goldfish (Yoshikubo et al 2005) and bone of sea bream (Socorro et al 2000). This suggests a possible direct effect of E 2 on bone and scale demineralization in teleosts, related to the strong demand in minerals for Vg production in oviparous vertebrates.…”

Section: E 2 Action On Bone Demineralization: An Oviparous Featurementioning

confidence: 93%

Cortisol mobilizes mineral stores from vertebral skeleton in the European eel: an ancestral origin for glucocorticoid-induced osteoporosis?

Sbaihi

Rousseau

Baloche

et al. 2009

Journal of Endocrinology

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Endogenous excess cortisol and glucocorticoid (GC) therapy are a major cause of secondary osteoporosis in humans. Intense bone resorption can also be observed in other vertebrates such as migratory teleost fish at the time of reproductive migration and during fasting when large amounts of calcium and phosphate are required. Using a primitive teleost, the European eel, as a model, we investigated whether cortisol could play an ancestral role in the induction of vertebral skeleton demineralization. Different histological and histomorphometric methods were performed on vertebral samples of control and cortisoltreated eels. We demonstrated that cortisol induced a significant bone demineralization of eel vertebrae, as shown by significant decreases of the mineral ratio measured by incineration, and the degree of mineralization measured by quantitative microradiography of vertebral sections. Histology and image analysis of ultrathin microradiographs showed the induction by cortisol of different mechanisms of bone resorption, including periosteocytic osteolysis and osteoclastic resorption. Specificity of cortisol action was investigated by comparison with the effects of sex steroids. Whereas, testosterone had no effect, estradiol induced vertebral skeleton demineralization, an effect related to the stimulated synthesis of vitellogenin (Vg), an oviparous specific phospho-calciolipoprotein. By contrast, the cortisol demineralization effect was not related to any stimulation of Vg. This study demonstrates GC-induced bone demineralization in an adult non-mammalian vertebrate, which undergoes natural bone resorption during its life cycle. Our data suggest that the stimulatory action of cortisol on bone loss may represent an ancestral and conserved endocrine regulation in vertebrates.

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“…E 2 -specific binding [17] was detected in the scales of rainbow trout. However, a different action from E 2 -treated scales was obtained in OHPAH- scales.…”

Section: Discussionmentioning

confidence: 93%

Toxic effect of polycyclic aromatic hydrocarbon metabolites on fish bone metabolism

Hayakawa

Suzuki

Kitamura

et al. 2010

WIT Transactions on Ecology and the Environment

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Marine water is contaminated with polycyclic aromatic hydrocarbons (PAHs) from rivers and the atmosphere. Oil spilled from tankers or petroleum factories also causes marine pollution with PAHs. It is well known that PAHs, such as benzo [a]pyrene, show carcinogenicity and/or mutagenicity. In developing teleost fish, furthermore, it has been reported that spinal deformity was induced in Pacific herring and pink salmon by PAHs, although the detail mechanism of toxicity in teleosts is not elucidated yet. As a toxic pathway of PAHs in animals, the metabolic activation of PAHs in the presence of P450 is considered. In teleosts, as well as in mammals, it has been reported that PAHs are converted into monohydroxylated polycyclic aromatic hydrocarbons (OHPAHs) by an enzyme: cytochrome P4501A1. Thus, OHPAH might have a toxic effect in teleosts. In the present study, we examined the estrogenic activity of OHPAHs using the yeast-two hybrid assay system with human estrogen receptor ER) . As a result, we detected estrogenic activity in 4-hydroxybenz[a]anthracene (4-OHBaA). Then, the direct effect of 4-OHBaA on osteoclasts and osteoblasts in teleosts was examined using the assay system with fish scales, which contain osteoclasts, osteoblasts, and the bone matrix of two layers (bony layer: a thin, well-calcified external layer; a fibrillary layer: a thick, partially calcified layer). When the scales of goldfish and wrasse were incubated with 4-OHBaA, which showed agonistic activity in the yeast-two hybrid assay system described above, the suppressing effect was observed for both osteoclasts and osteoblasts. The osteoclastic and osteoblastic activities did not change with 1-hydroxypyrene, which has no binding activity to human ER. Thus, we conclude that PAH metabolites have a toxic effect on fish bone metabolism and that careful attention should be given to aquatic PAH contamination.

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The Presence of High-Affinity, Low-Capacity Estradiol-17β Binding in Rainbow Trout Scale Indicates a Possible Endocrine Route for the Regulation of Scale Resorption

Cited by 32 publications

References 50 publications

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

Cortisol mobilizes mineral stores from vertebral skeleton in the European eel: an ancestral origin for glucocorticoid-induced osteoporosis?

Toxic effect of polycyclic aromatic hydrocarbon metabolites on fish bone metabolism

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