Studies on ergothioncine. VI. Distribution and fluctuations of ergothioneine in rats.

Kawano, H.; Otani, Mieko; Takeyama, Keiko; Kawai, Yuichi; Mayumi, Tadanori; Hama, Takao

doi:10.1248/cpb.30.1760

Cited by 59 publications

(45 citation statements)

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“…Ergothioneine is widely distributed in biological systems, particularly in red blood cells of animals (Stowell, 1961), which present in high concentrations as a free form (Kawano et al, 1982) and in striated muscles of various animals (Hartman et al, 1988). To investigate the biochemical effect of LER in human body, we have first examined its levels in healthy human blood and its distribution pattern with respect to ages.…”

Section: Resultsmentioning

confidence: 99%

“…It was also found to occur in semen and various mammalian tissues, principally liver and kidneys (Melville, 1958;Mayumi et al, 1978). It is also found in the whole blood of pig (Heath et al, 1953) and rat (Kawano et al, 1982). The biosynthesis of LER via histidine from Claviceps purpurea and Neurospora crassa cultures were studied by different researchers (Heath et al, 1953;Melville et al, 1956) Despite a considerable amount of work on this compound, its exact mode of action remains to be established and also the question of its origin in the animal body to be resolved.…”

Section: Introductionmentioning

confidence: 99%

“…The interest in this compound was greatly stimulated by its subsequent discovery in blood, as a free form (Kawano et al, 1982). It was also found to occur in semen and various mammalian tissues, principally liver and kidneys (Melville, 1958;Mayumi et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

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L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

Kumosani

2001

Exp Mol Med

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Ergothioneine is widely distributed in biological systems, particularly in red blood cells of animals. However, it's functional role in human body is not well understood. In order to investigate the biochemical effect of L-ergothioneine, its concentration changes in human blood with respect to ages in healthy individuals was first investigated. L-ergothioneine concentrations in the blood of Saudi males from western province at different stages of life were measured by the procedure of Carlsson et al., 1974. At early stages of life (1-10 years), the concentrations of LER is 1.5-2.0 mg/100 ml. It increases gradually at the age of 11-18 years where it reaches the maximum value of 3.7 mg/100 ml. Then, it declines gradually to 3.0-2.3 mg/ 100 ml during the period of 19-50 years. An increase in the level of LER (2.8 mg/100 ml) was seen at the age of 51 + .

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

Kumosani

2001

Exp Mol Med

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“…By far, the highest levels of ET have been found in mushrooms (0.1-1 mg͞g dried material) (13). ET is rapidly cleared from the circulation and then avidly retained with minimal metabolism: the whole-body half-life of ingested ET in rats is Ϸ1 month (15). The content of ET varies greatly among tissues and is strongly dependent on its dietary level (14).…”

Section: Discussionmentioning

confidence: 99%

Discovery of the ergothioneine transporter

Gründemann

Harlfinger

Gölz

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

468

482

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“…However, steady-state ergothioneine level appears to be governed by OCTN1 according to the present findings (Table I). In addition, since ergothioneine is minimally biosynthesized or metabolized in animals (20,21,29,30), transporter(s) involved in its absorption and disposition would be likely to regulate the steady-state level of ergothioneine. Therefore, it is necessary to directly examine the function of OCTN1 in CD patients to clarify the possible relation between the lower ergothioneine level in CD patients ( Figure 6) and OCTN1 activity in those patients.…”

Section: Discussionmentioning

confidence: 99%

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

et al. 2010

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Purpose: Solute carrier, OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present study was to examine physiological roles of OCTN1. Methods:We first constructed octn1 gene knockout (octn1 -/-) mice. Metabolome analysis was then performed to identify substrates in vivo. The possible association of the substrate identified with diseased conditions was further examined. Results:The metabolome analysis of blood and several organs indicated complete deficiency of a naturally occurring potent antioxidant ergothioneine in octn1 -/-mice among 112 metabolites examined.Pharmacokinetic analyses after oral administration revealed the highest distribution to small intestines and extensive renal reabsorption of [ 3 H]ergothioneine, both of which were much reduced in octn1 -/-mice.The octn1 -/-mice exhibited greater susceptibility to intestinal inflammation under the ischemia and reperfusion model. The blood ergothioneine concentration was also much reduced in Japanese patients with Crohn's disease, compared with healthy volunteers and patients with another inflammatory bowel disease, ulcerative colitis. 4Conclusions: These results indicate that OCTN1 plays a pivotal role for maintenance of systemic and intestinal exposure of ergothioneine which could be important for protective effect against intestinal tissue injuries, providing a possible diagnostic tool to distinguish the inflammatory bowel diseases.

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Studies on ergothioncine. VI. Distribution and fluctuations of ergothioneine in rats.

Cited by 59 publications

References 0 publications

L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

Discovery of the ergothioneine transporter

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

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