L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

Abstract

Ergothioneine is widely distributed in biological systems, particularly in red blood cells of animals. However, it's functional role in human body is not well understood. In order to investigate the biochemical effect of L-ergothioneine, its concentration changes in human blood with respect to ages in healthy individuals was first investigated. L-ergothioneine concentrations in the blood of Saudi males from western province at different stages of life were measured by the procedure of Carlsson et al., 1974. At early stages of life (1-10 years), the concentrations of LER is 1.5-2.0 mg/100 ml. It increases gradually at the age of 11-18 years where it reaches the maximum value of 3.7 mg/100 ml. Then, it declines gradually to 3.0-2.3 mg/ 100 ml during the period of 19-50 years. An increase in the level of LER (2.8 mg/100 ml) was seen at the age of 51 + .

Quantification of L‐ergothioneine in whole blood by hydrophilic interaction ultra‐performance liquid chromatography and UV‐detection

“…The average ERT level (mean ± SD) in real samples was 55.99 ± 49.66 mol/L (females 62.14 ± 57.62; males 49.84 ± 39.76 mol/L) and, on average, our results were consistent with the values reported by other authors for whole blood ERT content [32]. Moreover, as already reported in other studies [33], they show a considerable variation in the SD of ERT concentration, which could reflect the different feeding habits of the healthy subjects.…”

Serum Zinc in Infants and Preschool Children in the Jeddah Area: Effect of Diet and Diarrhea in Relation to Growth

“…This was noted in an earlier report on serum zinc levels of individuals in the same area of the country. 20 However, our calculated means in Tables 1 and 3 are higher than the earlier reported means for subjects above one year of age, and close to the mean for the younger subjects. Two factors are likely to cause the noted changes with age; the first is the dietary intake that changes as the infant grows, and the second is the incidence of diarrhea.…”

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

“…Ergothioneine can accumulate to high levels in some human and animal tissues, including red blood cells (with basal levels of~125 lM and~220 lM in human and mouse whole blood, respectively, and millimolar levels reported in red blood cells [52,53]), liver and spleen (with basal levels of~350 lmolÁg À1 tissue and 100 lmolÁg À1 tissue in mouse liver and spleen, respectively) [22,31-33]. Our recent study [33] demonstrated that when ET is orally administered to mice, it accumulates rapidly in the liver and blood cells but also enters most (or perhaps all) other tissues, including brain, heart, lung, kidney, spleen and eye.…”