Studies on drug release kinetics and antibacterial activity against drug-resistant bacteria of cefotaxime sodium loaded layered double hydroxide–fenugreek nanohybrid

Komarala, Eswaravara Prasadarao; Doshi, Sejal; Thiyagarajan, Shankar; Aslam, M.; Bahadur, D.

doi:10.1039/c7nj03622a

Cited by 27 publications

(17 citation statements)

References 38 publications

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Section: Antibacterial Activity Of 2d Materials Beyond Gmsmentioning

confidence: 99%

“…Komarala et al. established a cefotaxime (Cefo)‐intercalated Mg‐Al LDH‐fenugreek (CLF) nanohybrid and observed comparable antibacterial efficacy of the nanohybrid towards both E. coli and cefotaxime resistance extended spectrum beta‐lactamase E. coli ( E. coli ESBL) (Figure h), whereas E. coli ESBL can survive under an equivalent concentration of Cefo only . In addition to these small molecules, antibacterial macromolecules, such as lysozyme and a type of bacteriocin (avicin A), have also been immobilized on LDHs to achieve the concerted effect of killing pathogens and enhancing chemical stability.…”

Section: Antibacterial Activity Of 2d Materials Beyond Gmsmentioning

confidence: 99%

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Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

110

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Since the "birth" of graphene in 2004, two-dimensional (2D) materials have attracted unprecedented research interest from scientists and have stimulated numerous applications in various fields, such as electronic/optical devices, energy storage, catalysis, sensors, and biomedicine. In this review, we summarize recent advances in the antimicrobial applications of 2D materials, such as graphene materials (GMs), layered double hydroxides (LDHs), transition-metal dichalcogenides (TMDs), graphitic carbon nitride (g-C N ), MXenes, black phosphorus (BP), and their derivatives. This review also correlates the unique physicochemical properties of 2D materials with their antimicrobial activities. Finally, some current challenges and future perspectives in this field are also presented.

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Section: Antibacterial Activity Of 2d Materials Beyond Gmsmentioning

confidence: 99%

Section: Antibacterial Activity Of 2d Materials Beyond Gmsmentioning

confidence: 99%

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

110

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“…Besides, the basal spacing of the (003) plane decreased from 7.82271Å in the case of LDH to 7.58808Å in Zn-Al LDH/cefotax, which revealed a less effective penetration of cefotax into the Zn-Al/LDH interlayers. [39][40][41] This diminishing may refer to one of the following reasons: the removal of water molecules, rearrangement of Zn/ Al ions, and partial replacement of chloride ions by cefotax molecules or the adsorption of cefotax molecules on the surface of LDH via hydrogen-bonding, 42 as per the scheme submitted. Also, the d003 of the LDH and LDH/cefotax Nano composite was double that of d006 signifying a good layer structure.…”

Section: Resultsmentioning

confidence: 99%

“…The absorbance ratio showed an increase in the case of Zn-Al LDH/cefotax nanocomposite (0.9709) more than that of Zn-Al LDH (0.807), indicating the hydrogen bonding interaction between the LDH and the loaded cefotax. 42 3.1.3. Microscopic study FESEM and TEM.…”

Section: Resultsmentioning

confidence: 99%

Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection

et al. 2020

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“…Recently, the use of LDHs to control the release of drugs has opened up new applications of these layered solids in cosmetics and medicine . However, there are still a few studies that elucidate the mechanism behind the release of these substances from LDHs.…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing

Malafatti

Bernardo

Moreira

et al. 2020

Polymers for Advanced Techs

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Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active agents. Silver sulfadiazine (SDZ) is an antibiotic used to control bacterial infection in external wounds. Aiming to combine the properties of PLA and SDZ, hydrotalcite ([Mg-Al]-LDH) was used as a host matrix to obtain an antimicrobial system efficient in delivering SDZ from electrospun PLA scaffolds intended for wound skin healing. The structural reconstruction method was successfully applied to intercalate silver sulfadiazine in the [Mg-Al]-LDH, as evidenced by X-ray diffraction and thermogravimetric analyses. Observations by scanning electron microscopy revealed a good distribution of SDZ-[Mg-Al]-LDH within the PLA scaffold. Kinetics studies revealed a slow release of SDZ from the PLA scaffold due to the intercalation in the [Mg-Al]-LDH. In vitro antimicrobial tests indicated a significant inhibitory effect of SDZ-[Mg-Al]-LDH against Escherichia coli and Staphylococcus aureus. This antibacterial activity was sustained in the 2.5-wt% SDZ-[Mg-Al]-LDH-loaded PLA nanofibers, which also displayed excellent biocompatibility towards human cells. The multifunctionality of the PLA/SDZ-[Mg-Al]-LDH scaffold reported here is of great significance for various transdermal applications. K E Y W O R D S drug release, electrospinning, hydrotalcite, sulfadiazine silver, wound healing

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Studies on drug release kinetics and antibacterial activity against drug-resistant bacteria of cefotaxime sodium loaded layered double hydroxide–fenugreek nanohybrid

Abstract: Antibacterial activity of a CLF nanohybrid against E. coli 949 ESBL cefotaxime-resistant bacteria via the interaction of penicillin binding protein.

Cited by 27 publications

References 38 publications

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing

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