Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection

Elhaleem, Maha B. Abd; Farghali, Ahmed A.; El-Shahawy, Ahmed A. G.; El-Ela, Fatma I. Abo; Eldine, Zienab E.; Mahmoud, Rehab

doi:10.1039/c9ra08355c

Cited by 21 publications

(9 citation statements)

References 81 publications

(76 reference statements)

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“…54 Through FTIR investigations, some levo bands were observed in the Zn-Al LDH/levo nanocomposite spectrum, which conrmed the successful loading of levo onto the Zn-Al LDH surface, as observed in the appearance of peaks at 2037, 1497 and 1087-1036 cm À1 , which are related to C-O-C, C-O and C-F, respectively. 28,47,50,[54][55][56][57][58] Besides this, some peaks were shied to a lower wavenumber, as shown in Table 2. 3.1.3.…”

Section: Resultsmentioning

confidence: 78%

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Sustainable waste management and recycling of Zn–Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial

et al. 2020

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Section: Resultsmentioning

confidence: 78%

“…2). 46,47 The XRD pattern of the prepared Zn-Al LDH conrmed its high crystallinity via the sharpness of its diffraction peaks. The native Zn-Al LDH diffraction peaks were in good agreement with those of a synthetic hydrotalcite-like compound with the ICDD card no.…”

Section: Resultsmentioning

confidence: 99%

Sustainable waste management and recycling of Zn–Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial

et al. 2020

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“…The predicted qe (q(e,cal)) is extremely similar to the experimentally determined equilibrium q(e,exp) (Tables 3 – 5 ). As a result, the avrami and mixed 1, 2 order adsorption mechanisms are dominant for the adsorption of deltamethrin onto Zn-Al LDH/GA LDH, Zn-Fe LDH, and Fe-oxide nanoparticles, implying that physical adsorption and intermolecular intermolecular hydrogen bonding and chemical bonds were the rate determining steps through electrostatic interactions and intermolecular [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

New insight on some selected nanoparticles as an effective adsorbent toward diminishing the health risk of deltamethrin contaminated water

et al. 2021

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Deltamethrin is a widely used insecticide that kills a wide variety of insects and ticks. Deltamethrin resistance develops as a result of intensive, repeated use, as well as increased environmental contamination and a negative impact on public health. Its negative impact on aquatic ecology and human health necessitated the development of a new technique for environmental remediation and wastewater treatment, such as the use of nanotechnology. The co-precipitation method was used to create Zn-Fe/LDH, Zn-AL-GA/LDH, and Fe-oxide nanoparticles (NPs), which were then characterized using XRD, FT-IR, FE-SEM, and HR-TEM. The kinetic study of adsorption test revealed that these NPs were effective at removing deltamethrin from wastewater. The larval packet test, which involved applying freshly adsorbed deltamethrin nanocomposites (48 hours after adsorption), and the comet assay test were used to confirm that deltamethrin had lost its acaricidal efficacy. The kinetics of the deltamethrin adsorption process was investigated using several kinetic models at pH 7, initial concentration of deltamethrin 40 ppm and temperature 25°C. Within the first 60 min, the results indicated efficient adsorption performance in deltamethrin removal, the maximum adsorption capacity was 27.56 mg/L, 17.60 mg/L, and 3.06 mg/L with the Zn-Al LDH/GA, Zn-Fe LDH, and Fe Oxide, respectively. On tick larvae, the results of the freshly adsorbed DNC bioassay revealed larval mortality. This suggests that deltamethrin’s acaricidal activity is still active. However, applying DNCs to tick larvae 48 hours after adsorption had no lethal effect, indicating that deltamethrin had lost its acaricidal activity. The latter result corroborated the results of the adsorption test’s kinetic study. Furthermore, the comet assay revealed that commercial deltamethrin caused 28.51% DNA damage in tick cells, which was significantly higher than any DNC. In conclusion, the NPs used play an important role in deltamethrin decontamination in water, resulting in reduced public health risk. As a result, these NPs could be used as a method of environmental remediation.

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“…During the past several decades, various raw materials and techniques have been expanded into the field of drug delivery, an interdisciplinary application field [ 14 , 15 , 16 , 17 ]. Among all sorts of raw materials (such as inorganic nanoparticles, carbon nano tubes, graphene, and organic molecules) [ 18 , 19 , 20 , 21 ], biomacromolecules, which often have a natural source, have received increased attention due to their fine biocompatibility, low toxicity, abundance in nature, and, often, their ease of processing [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

et al. 2021

Biomolecules

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The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

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Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection

Abstract: This study succeeded to formulate, characterize, and investigate cefotax release and kinetics, and to compare cetofax with other known antibacterial agents.

Cited by 21 publications

References 81 publications

Sustainable waste management and recycling of Zn–Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial

Sustainable waste management and recycling of Zn–Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial

New insight on some selected nanoparticles as an effective adsorbent toward diminishing the health risk of deltamethrin contaminated water

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

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