Studies on age related changes in the lipids of mouse liver microsomes

Hawcroft, D. M.; Martin, P.A.

doi:10.1016/0047-6374(74)90010-4

Cited by 31 publications

(4 citation statements)

References 18 publications

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“…Other authors support the idea that the protective effect of cholesterol on haemolysis could be based on a reduction in membrane lipid peroxides [32] . This effect could be linked with the change in phospholipid packing, such that it makes them less accessible to free radicals.…”

Section: Discussionmentioning

confidence: 79%

“…Erythrocytes do not synthesize cholesterol and depend on exchange from the plasma for renewal: a high plasma cholesterol level may infl uence plasma membrane cholesterol content [9] . The plasma membrane properties are related to their lipid composition: decreased unsaturated fatty acids and/or in- creased cholesterol are generally implicated in changes of membrane fl uidity [16,[31][32][33] . An increase in membrane cholesterol limits the rotation and mobility of fatty acid chains in the bilayer by condensing hydrophobic interactions, which leads to increased microviscosity of membrane lipids.…”

Section: Discussionmentioning

confidence: 99%

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Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

et al. 2005

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Aims: The purpose of the present study was to evaluate the ability of calcic and magnesic-sulphate-sulphurous spring mineral water (SMW) to reduce total and erythrocyte plasma membrane cholesterol in rats fed a cholesterol-rich diet. Methods: By using different fluorescent probes, 1,6-diphenyl-1,3,5-hexatriene (DPH), 1-[4-(trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene (TMA-DPH) and Laurdan, a possible correlation was evaluated between cholesterol content changes of the membranes and membrane fluidity. Results: The results clearly show that hydropinic treatment reduced cholesterol level. No significant change was observed in DPH and TMA-DPH anisotropy values. By using Laurdan, an increase was observed in generalized polarization (GP₃₄₀) in both groups of rats (the one that drank tap water and the one that drank SMW) compared with the controls. The rate of haemolysis was reduced in those erythrocyte suspensions in which cholesterol was increased, even if the enzymatic activity of glutathione peroxidase and catalase decreased. Conclusion: Hydropinic treatment with SMW is of interest from the biomedical point of view, because it could represent an alternative approach in interventions aimed at ameliorating biological injury deriving from hypercholesterolaemia.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

et al. 2005

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“…The ratio between phospholipid and cholesterol content (PL/C ratio) [27,181 and the degree of saturation of the acyl-chains [24, 291 are two of the most important chemical determinants of membrane fluidity. An age related decrease in the cell membrane PL/C ratio has been reported [30]; moreover Iacono et al found in human platelets a decrease in fatty acid unsaturation index and in the phosphatidylethanolamine/phosphatidylcholine ratio [3 11. Thus the modifications in membrane fluidity due to age related changes [32] could lead to a reduced exposition of the PG12 receptors on platelet surface.…”

Section: Discussionmentioning

confidence: 99%

Age related changes of platelet prostacyclin receptors in humans

Modesti¹,

Fortini²,

Abbate³

et al. 1985

Eur J Clin Investigation

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Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 +/- 16 (mean +/- SD) high affinity receptors/platelet and 3509 +/- 529 low affinity receptors/platelet whereas the old subjects had 86 +/- 14 high affinity receptors/platelet (P less than 0.02) and 2471 +/- 640 low affinity receptors/platelet (P less than 0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P less than 0.001 for the high affinity class and r = -0.65, P less than 0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P less than 0.30 and P less than 0.90 respectively for high and low affinity receptors).

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“…Model organisms have been crucial in enhancing our understanding of the role of different lipid classes in regulation of ageing rate, lifespan and prevention or acceleration of age-related diseases 3 . The first association between lipid composition and ageing rate was demonstrated in Caenorhabditis elegans 4 , Drosophila melanogaster 5 , laboratory Mus musculus 6 and the budding yeast Saccharomyces cerevisiae. In Saccharomyces cerevisiae 7 , mutations in insulin growth factor-2 pathway and the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway increased lipid storage and the elevated lipid storage is associated with increased lifespan and reduced reproduction 3 .…”

mentioning

confidence: 99%

Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna

Constantinou

Southam

Kvist

et al. 2020

Sci Rep

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Lipids play a significant role in regulation of health and disease. To enhance our understanding of the role of lipids in regulation of lifespan and healthspan additional studies are required. Here, UHpLc-MS/ MS lipidomics was used to measure dynamic changes in lipid composition as a function of age and gender in genetically identical male and female Daphnia magna with different average lifespans. We demonstrate statistically significant age-related changes in triglycerides (TG), diglycerides (DG), phosphatidylcholine, phosphatidylethanolamine, ceramide and sphingomyelin lipid groups, for example, in males, 17.04% of TG lipid species decline with age whilst 37.86% increase in relative intensity with age. In females, 23.16% decrease and 25.31% increase in relative intensity with age. Most interestingly, the rate and direction of change can differ between genetically identical female and male Daphnia magna, which could be the cause and/or the consequence of the different average lifespans between the two genetically identical genders. this study provides a benchmark dataset to understand how lipids alter as a function of age in genetically identical female and male species with different average lifespan and ageing rate.

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Studies on age related changes in the lipids of mouse liver microsomes

Cited by 31 publications

References 18 publications

Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

Age related changes of platelet prostacyclin receptors in humans

Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna

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