Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

Nasuti, Cinzia; Gabbianelli, Rosita; Cantalamessa, Franco; Falcioni, Giancarlo

doi:10.1159/000084172

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…The possible effects of demineralized water on kidney tissue need to be explored in further research. In contrast to research that states that the HDL and LDL levels are affected by the consumption of mineral-rich water (Nasuti et al, 2005). and that, depending on the duration of consumption, the total cholesterol and LDL cholesterol levels decrease while HDL levels increase (Granados et al, 2010), this research found that the consumption of either fresh, bottled, deionized and deionized water does not affect the blood total cholesterol, HDL and LDL cholesterols.…”

Section: Discussioncontrasting

confidence: 99%

Determination of Effects on Oxidant Antioxidant Balance and Some Biochemical Parameters Consumption of Bottled, Distilled and Deionized Thermal Water in Rats

Çevik¹,

Ulutaş²,

Demirel³

et al. 2016

Kocatepe Vet J

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The objective of this research is to determine the effects of the consumption of the bottled, distilled and deionized versions of thermal water taken from the Gazlıgöl district in the city of Afyonkarahisar on the oxidant -antioxidant balance and on certain biochemical parameters, along with possible effects on liver and kidney tissue. The research involved 6 rats in each group. The experiment group was given fresh, bottled, deionized and distilled thermal water for 30 days whereas the control group was given normal water. At the end of the experiment, rats' blood samples as well as liver, kidney and heart tissue samples were taken. The research determined that the hemoglobin level in rats that consumed bottled thermal water is considerably lower than those that consumed fresh and deionized water (p<0,05). The zinc level was meaningfully lower in rats that consumed distilled water than those in the other groups (p<0,05). There was no meaningful difference among the groups in terms of the liver and kidney tissues' MDA, GSH and SOD levels. Nevertheless, it was observed that the heart tissues' MDA level was higher in rats that consumed bottled and deionized water than those in other groups (p<0,01) whereas the GSH and SOD levels did not change. The histopathological examination of liver and kidney tissue showed certain pathological changes.The conclusion of the research is that thermal water does not have a positive effect on the organism.Key Words: Biochemical Parameters, Oxidant Antioxidant Balance, Thermal Water. Sıçanlarda Bekletilmiş, Distile ve Deiyonize Kaplıca Suyu Tüketilmesinin Oksidan Antioksidan Denge ve Bazı Biyokimyasal Parametreler Üzerine Etkisinin BelirlenmesiÖZ Bu çalışmada, Afyonkarahisar ilinin Gazlıgöl bölgesinden alınan kaplıca suyu ve bu suyun bekletilerek, distile ve deiyonize edilerek tüketilmesinin oksidan-antioksidan denge ve bazı biyokimyasal parametreler ile karaciğer ve böbrek dokusuna etkilerinin belirlenmesi amaçlanmıştır. Çalışmada her grupta 6 sıçan yer almıştır. 30 gün boyunca, deney grubundaki sıçanlara taze, bekletilmiş, deiyonize ve distile edilmiş kaplıca suyu, kontrol grubundakilere ise normal su verilmiştir. Deneme sonunda sıçanlardan kan numuneleri ile karaciğer, böbrek ve kalp doku örnekleri alınmıştır.Hemoglobin değeri bekletilmiş kaplıca suyu tüketen sıçanlarda taze ve deiyonize tüketen sıçanlara göre önemli oranda düşük olduğu gözlenmiştir(p<0,05). Distile edilmiş kaplıca suyu tüketen sıçanlarda Çinko değerinde diğer gruplara göre anlamlı (p<0,05) bir düşüş oluşmuştur. Karaciğer ve böbrek dokusu MDA, GSH ve SOD düzeyleri bakımından gruplar arasında anlamlı bir değişim gözlenmemiştir. Buna karşın, kalp dokusunda MDA düzeylerinin bekletilmiş ve deiyonize kaplıca suyu tüketen sıçanlarda diğer gruptakilere göre daha yüksek olduğu (p<0,01), GSH ile SOD düzeylerinin ise değişmediği saptanmıştır. Karaciğer ve böbrek dokusu hispatolojik incelemesinde birtakım patolojik değişiklikler tespit edilmiştir. Sonuç olarak çalışmada kullanılan kaplıca suyunun organizmada olumlu ...

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Section: Discussioncontrasting

confidence: 99%

Determination of Effects on Oxidant Antioxidant Balance and Some Biochemical Parameters Consumption of Bottled, Distilled and Deionized Thermal Water in Rats

Çevik¹,

Ulutaş²,

Demirel³

et al. 2016

Kocatepe Vet J

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“…Some authors underlined the importance of hydropinic treatment with calcic and magnesic-sulphate-sulphurous spring mineral water from the biomedical point of view, because it could represent an alternative approach in the interventions aimed at ameliorating biological injury deriving from hypercholesterolaemia. To evaluate the ability to reduce total and erythrocyte plasma membrane cholesterol by using calcic and magnesic-sulphate-sulphurous spring mineral water, a few studies have been performed on rats fed with a cholesterol-rich diet (Nasuti et al, 2005). In these studies, the rate of haemolysis was reduced in those erythrocyte suspensions in which cholesterol was increased, even if the enzymatic activity of glutathione peroxidase and catalase decreased.…”

Section: Biochemical Effects Of Mineral Watersmentioning

confidence: 99%

Drinking mineral waters: biochemical effects and health implications the state-of-the-art

Albertini¹,

Dachà²,

Teodori

et al. 2007

IJENVH

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Spring mineral water might have the properties favourable to health, which should be assessed by clinical and pharmacological analyses. Efforts have recently been made to approach the study of the validity of spring mineral water curative therapies by advanced biochemical research on both animal models and humans. Owing to the paramount interest and the growing recent use of drinking mineral waters, a need for a rigorous scientific approach arises. The therapeutic action of drinking mineral waters has been demonstrated to have important biochemical implications. However, some adverse events during health resorts cure must be considered and investigated. This paper reviews the state-of-the-art on the biochemical studies related to the effects of drinking mineral water. In the light of the review of the literature on the matter, we conclude that further studies are necessary to avoid any possible implication for public health connected with mineral water misuse.

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“…Of note, investigations of mineral waters in animal models presented conflicting [8,9]. A first study reported that, in fasting state, the consumption of Calcium/magnesium rich waters decreased plasma total cholesterol and LDL cholesterol in rat [9] while another study showed an increase in HDL cholesterol and stabilization of LDL cholesterol in rat fed cholesterol rich diet, with an active conversion of cholesterol into bile acid [10]. Investigations in human also reported some positive effects of mineral water consumption.…”

Section: Introductionmentioning

confidence: 99%

Effect of a high bicarbonate mineral water on fasting and postprandial lipemia in moderately hypercholesterolemic subjects: a pilot study

et al. 2013

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BackgroundDuring postprandial state, TG concentration is increasing and HDL cholesterol decreasing, leading to a transitory pro-atherosclerotic profile. Previous studies have reported that bicarbonate water improve postprandial lipemia. The objective of this study was to analyze the effect of a strongly bicarbonated mineral water on lipoprotein levels during fasting and postprandial state.MethodsA controlled, randomised, double-blind cross-over design was conducted in 12 moderately hypercholesterolemic subjects after a daily ingestion of 1.25 L of mineral (SY) or low mineral water during eight weeks separated by a one week wash-out period. Blood samples were collected in first visit to the hospital (V1) before water consumption (referent or SY) and in a second visit (V2) after eight week water consumption period. The effect of the consumed water was studied in fasting and in postprandial state during ingestion of a meal and 0.5 L of water.ResultsComparison of data between V1 and V2 after SY consumption showed a significant decrease in triglyceridemia (23%), VLDL TG (31%) and tendency to a decrease of VLDL cholesterol (p = 0.066) at fasting state. Whatever the consumed water during postprandial state, the measurement of total areas under curves did not show a significant difference. No difference was observed between SY and referent water consumption for measured parameters at fasting and postprandial state.ConclusionWhen subjects consumed SY we showed a decrease of their basal TG and VLDLTG. The unexpected absence of effect of high mineralized water on postprandial lipemia, probably related to experimental conditions, is discussed in the discussion section.

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Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

Cited by 7 publications

References 62 publications

Determination of Effects on Oxidant Antioxidant Balance and Some Biochemical Parameters Consumption of Bottled, Distilled and Deionized Thermal Water in Rats

Determination of Effects on Oxidant Antioxidant Balance and Some Biochemical Parameters Consumption of Bottled, Distilled and Deionized Thermal Water in Rats

Drinking mineral waters: biochemical effects and health implications the state-of-the-art

Effect of a high bicarbonate mineral water on fasting and postprandial lipemia in moderately hypercholesterolemic subjects: a pilot study

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