1956
DOI: 10.3891/acta.chem.scand.10-1042c
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Studies on a Thrombin-coagulable Protein in Blood Platelets.

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1969
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Cited by 7 publications
(9 citation statements)
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“…Thus, a Mg+z-or Ca+?-activated ATPase was identified in isolated synaptic vesicles of rat brain (139,140), and a similar ATPase was isolated from whole brain of the rat and cat (141) and characterized as having properties similar to those of muscle actomyosin and exhibiting an affinity for colchicine binding (142). A contractile protein was also isolated from human platelets (143) which was postulated to play a role in release of histamine and serotonin from these cells. Poisner (144) demonstrated the existence of an actomyosin-like protein in the bovine adrenal medulla, which could participate in the secretory mechanism of catecholamines.…”
Section: When the Gland Is Stimulated Through The Splanchnic Nerve Thmentioning
confidence: 99%
See 1 more Smart Citation
“…Thus, a Mg+z-or Ca+?-activated ATPase was identified in isolated synaptic vesicles of rat brain (139,140), and a similar ATPase was isolated from whole brain of the rat and cat (141) and characterized as having properties similar to those of muscle actomyosin and exhibiting an affinity for colchicine binding (142). A contractile protein was also isolated from human platelets (143) which was postulated to play a role in release of histamine and serotonin from these cells. Poisner (144) demonstrated the existence of an actomyosin-like protein in the bovine adrenal medulla, which could participate in the secretory mechanism of catecholamines.…”
Section: When the Gland Is Stimulated Through The Splanchnic Nerve Thmentioning
confidence: 99%
“…In view of the almost universal requirement for calcium in release of secretory products (81 and to be discussed later), Whittaker (94), referring to the possible role of microtubules in secretion, postulated that "if the walls of such tubules were made up of a macromolecule which changed configuration in the presence of calcium ions in such a way as to enlarge the lumen of the tubules, a basis might be provided for the well known essential role of calcium ions in excitation-secretion coupling." Because of the similarities between microtubule protein and actin (104), it is entirely possible that the "macromolecules" postulated by Whittaker (94) may actually constitute the contractile actomyosin isolated from secretory cells (139)(140)(141)(142)(143)(144). Rahwan…”
Section: When the Gland Is Stimulated Through The Splanchnic Nerve Thmentioning
confidence: 99%
“…Morphologically, thrombin induces platelet swelling, followed by degradation, pseudopod formation, platelet aggregation and fusion [12]. Physiologically, thrombin triggers the release of platelet contents [13]. Thrombin also has a profound influence on platelet metabolism ; it increases the utilization and resynthesis .…”
Section: Cellular Integritymentioning
confidence: 99%
“…Cytochalasin A inhibited aggregation completely at 20,ug/ml (42&M), but cytochalasin B only partially at 100lg/ml (209jzM). Clot retraction was inhibited completely by 4pg/ml of cytochalasin A and by 20,g/ml of cytochalasin B. Cytochalasin A (but not cytochalasin B) reacted with added cysteine, which blocked its effects.Thrombosthenin (platelet actomyosin) was extracted from pig platelets (Grette, 1962; Haslam & Mustard, 1969). The effects of 0.lmM-ATP on the turbidity of stirred suspensions of thrombosthenin in 60mM-KCI at pH7.0 were recorded.…”
mentioning
confidence: 99%