1972
DOI: 10.1042/bj1270034pa
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Inhibition of blood platelet function by cytochalasins: effects on thrombosthenin and on glucose metabolism

Abstract: in the inhibitor molecule was found to have a profound effect on the inhibition constant of the acid. Saturated dicarboxylic acids, with the exception of oxalate, were less inhibitory as the molecular weight increased. A cis effect was observed in the inhibition by unsaturated organic acids; compounds with two cis-carboxyl groups were much more inhibitory than the corresponding trans-isomers. This position effect was investigated quantitatively by measurement of the distances between carboxyl groups in space-f… Show more

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Cited by 30 publications
(7 citation statements)
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“…Platelets were used because in these cells cytochalasin B inhibits utilization of exogenous glucose (23) and affects motility in the form of blood clot retraction (1,17,23,24) and pseudopod formation (1).…”
Section: Binding Of Cytochalasin B To Cellular Components Of Bovine Pmentioning
confidence: 99%
“…Platelets were used because in these cells cytochalasin B inhibits utilization of exogenous glucose (23) and affects motility in the form of blood clot retraction (1,17,23,24) and pseudopod formation (1).…”
Section: Binding Of Cytochalasin B To Cellular Components Of Bovine Pmentioning
confidence: 99%
“…Other compounds which have also been reported to inhibit platelet function include the methylxanthines caffeine and theophylline (Ardlie et al, 1967;Brinson, 1972;Mustard and Packham, 1970), papaverine (Markwardt et al, 1967;Born and Mills, 1969), adenine compounds such as adenosine, AMP and ATP (Born and Cross, 1963a;Mustard and Packham, 1970), colchicine (White, 1968b), cytochalasins A and B (Shepro et al, 1970;White, 1971a ;Haslam, 1972), local anaesthetics such as lignocaine and cinchocaine (0 'Brien, 1961(0 'Brien, , 1962Aledort and Niemetz, 1968) , and ketolactones (Bicher and Beemer, 1971).…”
Section: Other Drugsmentioning
confidence: 99%
“…Platelets are known to transport glucose actively by a carrier mechanism (Solomon and Gaut, 1970), and CB inhibits this transport (Haslam, 1972). Thus, it is very likely that the low affinity (KD o 1.4 x l M) glucose sensitive CBbinding observed here also is intimately related to the glucose carrier.…”
Section: Discussionmentioning
confidence: 69%