Studies on a New Type of Genetically-Determined Quasisterility in the House Mouse

Rajasekarasetty, M. R.

doi:10.1016/s0015-0282(16)31509-6

Cited by 20 publications

(8 citation statements)

References 20 publications

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“…She mentioned that the types of abnormal heads were similar to those seen by Rajasekarasetty (1954). Judging from the pictures, they resembled the sperm¬ atozoa in Classes 2 and 3 of the present classification, which were also found in the oviduct (Table 1), although their percentage was greatly reduced in the oviducal flushings when compared with the uterine contents.…”

Section: Discussionsupporting

confidence: 69%

The Passage of Abnormal Spermatozoa Through the Uterotubal Junction of the Mouse

Krzanowska¹

1974

Reproduction

108

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Summary. Adult female mice of an outbred strain and of the inbred C57BL strain were naturally or artificially inseminated with spermatozoa from 6-to 14-week-old males belonging to two inbred strains, C57BL and KE. Several hours after insemination, the females were killed and examined for the percentage of spermatozoa with morphologically abnormal heads found in the uterus and in the oviducal flushings. According to the degree of abnormality, misshapen spermatozoa were divided into five classes. In young KE males, large spermatozoa were observed and designated as diploid. The proportion of abnormal forms in the uterus depended on the strain and on the age of the males, and was highest in the group inseminated with spermatozoa from young C57BL strain mice. The proportion of abnormal spermatozoa in the oviducal flushings was greatly reduced, although positively related to the percentage of abnormalities in the uterus. This applied particularly to slight abnormalities, their percentage being about three times higher in the uterus than in the oviduct. Spermatozoa with severe abnormalities were either not found in the oviduct or their proportion was reduced more than ten times.The uterotubal junction appears to function as a barrier against morphologically abnormal spermatozoa, especially against severely deformed ones, although its selective action is not absolutely effective.

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Section: Discussionsupporting

confidence: 69%

The Passage of Abnormal Spermatozoa Through the Uterotubal Junction of the Mouse

Krzanowska¹

1974

Reproduction

108

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“…Electron microscope examination showed a thickened mid-piece due to the presence of either a cytoplasmic droplet or pseudo-droplet similar to that described by Blom & Birch-Andersen (1968) in bulls. Rajasekarasetty (1954) has reported that in certain mouse genotypes, 14 to 58% of the spermatozoa have abnormalities involving the sperm nucleus and acrosome.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural Tail Defects in the Spermatozoa From Two Men Attending a Subfertility Clinic

Ross¹,

Christie²,

Edmond³

1973

Reproduction

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Similar ultrastructural defects were found in the spermatozoa of two oligospermic men attending a subfertility clinic. The majority of spermatozoa had a mid-piece of grossly abnormal morphology and the diameter of the tail was increased, due to an excess of outer-sheath fibres. Extra, as well as missing, axial-filament fibres were also seen. In both cases, only a very small proportion of the spermatozoa were motile.A testicular biopsy was performed on each man and although the histological appearance was normal, abnormal spermatozoa were seen in thin sections examined by electron microscopy.

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“…Braden and Gluecksohn-W aelsch (1958) support these findings for they showed that some of the more fertile genotypes (V / V) produced a higher proportion of morphologically abnormal sperm than did the less fertile or sterile genotypes (V/L, L/L). Rajasekarasetty (1954), on the other hand, concluded that morphological abnormality was an important factor and could result in the number of normal spermatozoa falling below a threshold value in V/L genotypes, thus reducing or preventing fertilization.…”

Section: Resultsmentioning

confidence: 99%

“…Subjective classifications (0, 1, 2, 3, and 4) were made of the relative numbers of sperm and their motility. One hundred sperm were selected at random and estimates of morphological abnormality made on a similar basis to that of Bryson (1943) and Rajasekarasetty (1954).…”

Section: (B) Sperm From the Vas Deferensmentioning

confidence: 99%

“…These combinations are as follows: (1) compounds of two different lethals, L/L (Bryson 1943;Braden and Gluecksohn-Waelsch 1958); (2) compounds of one lethal and one viable, L/V (Gluecksohn-Waelsch, Segal, and Fitch 1950;Rajasekarasetty 1954;Braden and Gluecksohn-Waelsch 1958); (3) compounds of two different or homozygous viables, V/V (Braden and Gluecksohn-Waelsch 1958); (4) compounds of one lethal and one viable male sterile, L/VMS (Bennett and Dunn 1967); (5) compounds of different or homozygous wild viable male steriles, VMS/VMS (Bennett and Dunn 1967). Although this latter type has been observed and the three alleles t W2 , t W8 , andt W36 have been found to be completely male sterile when homozygous, no detailed study has been carried out.…”

Section: Introductionmentioning

confidence: 99%

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Male Sterility in Mice Homozygous for the Tw2 Allele

Pg¹

1968

Aust. Jnl. Of Bio. Sci.

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SummaryThe causes of sterility in males homozygous for the male sterile viable t w2 allele were investigated. The numbers, motility, and morphology of sperm from sterile and fertile males in the vas deferens, and in the uterus and fallopian tubes of females inseminated by these males were examined.High morphological abnormality was found in sperm from sterile males, and also a significant reduction in numbers and motility was observed. No sperm from these males reached the fallopian tubes. Significantly lower testes weights of sterile males further suggested disturbed spermatogenesis. There are indications that the cause of sterility may vary, depending on the particular combinations of t alleles.

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Studies on a New Type of Genetically-Determined Quasisterility in the House Mouse

Cited by 20 publications

References 20 publications

The Passage of Abnormal Spermatozoa Through the Uterotubal Junction of the Mouse

The Passage of Abnormal Spermatozoa Through the Uterotubal Junction of the Mouse

Ultrastructural Tail Defects in the Spermatozoa From Two Men Attending a Subfertility Clinic

Male Sterility in Mice Homozygous for the Tw2 Allele

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