Male Sterility in Mice Homozygous for the Tw2 Allele

Pg, Johnston

doi:10.1071/bi9680947

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…Spermatozoa seem to be of normal appearance, and the cause of sterility consists in the inability of spermatozoa to reach the potential sites of fertilization in the female genital tract (Bennett & Dunn, 1967). Phenotypically similar but genetically clearly different is the spermatogenesis breakdown in males homozygous for semilethaH alleles (Johnston, 1968;). …”

Section: Discussionmentioning

confidence: 99%

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculusL.)

Forejt¹,

Iványi²

1974

Genet. Res.

207

187

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The genetic control of the sterility of male hybrids between certain laboratory and wild mice (Mus musculus L.) is investigated. The observed sterility is, by definition, hybrid sterility since both parental forms (i.e. wild and laboratory mice) are fully fertile, their male offspring displaying small testes with arrest of spermatogenesis at the stage of spermatogenesis or primary spermatocytes. Results of genetic analysis as well as the failure to detect any chromosomal rearrangements point to a genie rather than a chromosomal type of hybrid sterility.Fifty-three wild males were classified into three sets, after mating with C57BL/10 inbred females, according to the fertility of their male progeny (set I -only sterile sons; set II -only fertile sons; set III -both fertile and sterile sons). The wild males of set I, which yield only sterile male offspring with C57BL/10 females, sire sterile sons also with females of the following inbred strains: A/Ph, BALB/c, DBA/1, and AKR/J, whereas the same wild males produce fertile offspring with females of C3H/Di, CBA/J, P/J, I/St and F/St inbred strains.The described hybrid sterility seems to be under the control of several independently segregating genes, one of them (proposed symbol Hst-1) being localized on chromosome 17 (linkage group IX), 6 cM distally from dominant T (Brachyury). A chance to search for the mechanism of hybrid sterility is provided by the finding of two laboratory inbred strains, C57BL/10 and C3H/Di, differing with respect to the Hybrid sterility genetic system only at the Hst-1 gene.Hst-1 is closely linked but apparently not identical with the sterility factor of recessive t alleles of the T locus. 13-2

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Section: Discussionmentioning

confidence: 99%

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculusL.)

Forejt¹,

Iványi²

1974

Genet. Res.

207

187

View full text Add to dashboard Cite

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“…Several of the effects of the region, are found to be preferentially or exclusively detectable in males. For example, males, but not females, homozygous for the semilethal t haplotypes (< w2 , t w8 , t w36 ) are sterile (Bennett & Dunn, 1967;Johnston, 1968), with testes reduced in weight, many areas of degeneration in their spermatogenic tubules, and few or no sperm apparent in ejaculates (Johnston, 1968). Many lethal t haplotypes are preferentially transmitted by male but not female heterozygotes (Chesley & Dunn, 1936;Dunn & Gluecksohn-Schoenheimer, 1939), and only males heterozygous for haplotypes of two different lethal complementation groups are sterile (Dunn, 1937).…”

Section: Introductionmentioning

confidence: 99%

Lethality of heterozygotes betweent-haplotype complementation groups of mouse: sex-related effect on lethality oft⁶/t^w5heterozygotes

Bechtol

1982

Genet. Res.

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The various lethal 2-haplotypes are divided into several complementation groups defined by lethality oit x /t y heterozygotes, and only partial complementation is usually observed in heterozygotes between t complementation groups. Several effects of the t region have been found to be preferentially or exclusively detectable in males. This paper describes results showing that the viability of t 6 /t wb heterozygotes is influenced by the sex of the embryo; female viability is only slightly reduced (viability ratio approximately 080), while male viability is far below normal (0-25).

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Major histocompatibility complex (MHC)‐linked genes affecting development

1983

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Genes affecting growth and development which are linked to the major histocompatibility complex have been found in the mouse (t-complex) and in the rat (growth and reproduction complex, grc), and there is some evidence that they also exist in humans. The genes of the t-complex have different effects depending upon the specific combinations involved: skeletal and fertility abnormalities, complete or partial embryonic mortality, high transmission ratios (segregation distortion) in males, high level of linkage disequilibrium with H-2, and suppression of recombination over the adjacent portion of the chromosome. The grc in the homozygous state causes small body size, sterility in the male and reduced fertility in the female, partial embryonic mortality, and a high level of linkage disequilibrium with RT1. It also interacts epistatically with the heterozygous Tal (tail anomaly lethal) gene to cause complete embryonic death. Mice carrying t-haplotypes and rats carrying the grc have an antigen in the male germ cells which cross-reacts very strongly (t-antigen). Suggestive evidence for such genes in humans comes from (1) studies on the relationship between skeletal defects and HLA haplotypes; (2) the association of specific HLA and complement haplotypes with a high transmission ratio in males, linkage disequilibrium among certain HLA and complement specificities and suppression of recombination in some MHC haplotypes; and (3) the lack of homozygotes in an isolated inbreeding population of desert nomads (Kel Kummer Tuaregs). In addition, immunogenetic studies on couples having chronic spontaneous abortions suggest that there is an unusually high incidence of homozygosity for the HLA-D/DR and HLA-A loci in these couples, and this finding is consistent with the presence of linked loci which behave like t or grc.

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Male Sterility in Mice Homozygous for the Tw2 Allele

Cited by 10 publications

References 3 publications

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculusL.)

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculusL.)

Lethality of heterozygotes betweent-haplotype complementation groups of mouse: sex-related effect on lethality oft⁶/t^w5heterozygotes

Major histocompatibility complex (MHC)‐linked genes affecting development

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Male Sterility in Mice Homozygous for the Tw2 Allele

Cited by 10 publications

References 3 publications

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculusL.)

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculusL.)

Lethality of heterozygotes betweent-haplotype complementation groups of mouse: sex-related effect on lethality oft6/tw5heterozygotes

Major histocompatibility complex (MHC)‐linked genes affecting development

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Lethality of heterozygotes betweent-haplotype complementation groups of mouse: sex-related effect on lethality oft⁶/t^w5heterozygotes