Studies of Transplanted Haematopoietic Tissue Utilizing a Modified Algire Back Chamber

Feleppa, Alfred E.; Meineke, Howard A.; McCuskey, Robert S.

doi:10.1111/j.1600-0609.1971.tb01958.x

Cited by 10 publications

References 10 publications

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Marrow adipose tissue: Response to erythropoiesis

1978

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A group of rabbits was treated chronically with phenylhydrazine t o induce hemolysis and stimulate erythropoiesis. The mean volume of the marrow fat cell of a control group of hematologically normal rabbits was 54.8 pl; the mean volume of the perinephric fat cell was 549.5 pl, a volume ratio, perinephric/marrow of 10: 1. In the experimental animals the mean volume of the marrow fat cell fell t o 25.9 pl; the volume of the perinephric fat cell was unchanged and the volume ratio, perinephric/marrow was 18: l . Fat cell volume studies performed on rabbits subjected t o chronic bleeding yielded comparable data. The l-C14 palmitate uptake (esterification capacity) calculated on a cell basis was the same for both marrow and perinephric fat cells and was unaffected by phenylhydrazine treatment. The fatty acid composition shows higher content of unsaturated fatty acids in the marrow fat than in the perinephric fat of the control animal. In the experimental animal there appears t o be a preferential release of the unsaturated fatty acid. The findings of the study suggest that increased hematopoiesis stimulates lipolysis of marrow fat cells, probably through the local release of a chemical substance. Marrow fat appears to be functionally related t o hematopoiesis rather than t o systemic fat storage. Marrow fat may be involved in the metabolic support of hematopoiesis.

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Marrow adipose tissue: Response to erythropoiesis

1978

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Increased bone marrow blood flow in acute hemolytic anemia is due to an increase of the erythropoiesis

Celada

1986

American J Hematol

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Hematopoiesis in the embryonic mouse spleen. II. Alterations after phenylhydrazine administration to the mothers

1975

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The effect of phenylhydrazine (PHZ) on the hematopoietic events in the embryonic spleen of C57Bl/6J mice was examined by light and electron microscopy. Following PHZ in injections to the mothers, the embryonic spleen revealed a marked increase in erythroid precursors, with a shift to mature cells. This phenomenon was part of a more generalized stimulation of erythorpoiesis, expressed by a shift to mature red cell precursors in the embryonic livers and an increase in the percentage of non-nucleated cells in the embryonic peripheral blood. Concomitantly stimulation of phagocytosis in the spleen of embryos in the early gestational days and increased vascularity were observed, and a later effect of granulocytopoietic stimulation. The effect on erythropoiesis in the embryonic spleen might be a sequence of erythropoietin stimulation, either in the mothers or the fetuses, due to anemia and hypoxia following PHZ injections.

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Studies of Transplanted Haematopoietic Tissue Utilizing a Modified Algire Back Chamber

Cited by 10 publications

References 10 publications

Marrow adipose tissue: Response to erythropoiesis

Marrow adipose tissue: Response to erythropoiesis

Increased bone marrow blood flow in acute hemolytic anemia is due to an increase of the erythropoiesis

Hematopoiesis in the embryonic mouse spleen. II. Alterations after phenylhydrazine administration to the mothers

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