Marrow adipose tissue: Response to erythropoiesis

Bathija, Ambika; Davis, Stephen D.; Trubowitz, Sidney

doi:10.1002/ajh.2830050406

Cited by 42 publications

(21 citation statements)

References 20 publications

(16 reference statements)

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“…Red marrow fat readily gives way to hematopoietic expansion during an increased demand to produce more blood cells. 34 All hematopoietic cells arise from the same multipotent hematopoietic stem cells that then become differentiated into erythrocytes, granulocytes, megakaryocytes, and lymphocytes. While this initial survey of bone and marrow in sleep-restricted rats does not permit us to discern the exact profile of hematopoietic changes, two components were revealed.…”

Section: Discussionmentioning

confidence: 99%

Chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats

Everson¹,

Folley²,

Toth

2012

Exp Biol Med (Maywood)

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Insufficient sleep over long durations of the lifespan is believed to adversely affect proper development and healthful aging, although how this might become manifested is unknown. In the present study, rats were repeatedly sleep restricted during 72 days to permit maladaptations to evolve, thereby permitting study. Densitometric and histomorphometric analyses were performed on harvested bone. In sleep-restricted rats, bone lined by osteoid was reduced 45-fold and osteoid thickness was decreased, compared with controls. This corresponded to a decrease in osteoblast number and activity. The percentage of bone lined by osteoclasts did not differ from that of controls. Plasma concentrations of an osteoclast marker (TRACP 5b) were increased in sleep-restricted rats, indicating increased bone resorption. The low amount of new bone formation without a reduction in bone resorption is diagnostic of osteopenia. Bone mineral density was decreased in femurs from sleep-restricted rats compared with control, indicating osteoporosis. Red marrow in sleep-restricted rats contained only 37% of the fat and more than twice the number of megakaryocytes compared to that of the control rats. These findings in marrow suggest changed plasticity and increased hematopoiesis. Plasma concentrations of insulin-like growth factor-1, a known, major mediator of osteoblast differentiation and the proliferation of progenitor cells, was decreased by 30% in sleep-restricted rats. Taken together, these findings suggest that chronically inadequate sleep affects bone metabolism and bone marrow composition in ways that have implications for development, aging, bone healing and repair, and blood cell differentiation.

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Section: Discussionmentioning

confidence: 99%

Chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats

Everson¹,

Folley²,

Toth

2012

Exp Biol Med (Maywood)

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“…A lipolysis associated with increased erythropoietic demand has also been observed in vivo following phenylhydrazine (PHZ), induced erythroid aplasia (Bathija et al, 1978). The effect of PHZ appears to be specifically directed to marrow fat; extramedullary adipose tissue is not affected.…”

Section: Erythropoiesis In Long-termmentioning

confidence: 95%

Stromal cell associated haemopoiesis

1982

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“…While most publications tend to regard bone marrow‐derived adipocytes and extramedullary adipocytes as one in the same, some studies reveal distinctions between the two, such as asynchronous development, cytochemical differences, and disparate starvation responses (Cohen and Gardner, 1965; Bathija et al, 1978; Tavassoli, 1978; Gimble et al, 1996; Kirkland et al, 2002). Data from these studies provide a rationale for the proposal that the microenvironment of the marrow might give rise to adipocytes with a unique function.…”

mentioning

confidence: 99%

Characterizing medullary and human mesenchymal stem cell‐derived adipocytes

MacKay

Tesar

Liang

et al. 2006

Journal Cellular Physiology

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Throughout postnatal years, medullary adipocytes (MAs) increase in both number and size; however, knowledge of these cells pales in comparison to that of other adipocyte depots. It is widely hypothesized that MAs derive from multipotent progenitor cells of the bone marrow, such as human mesenchymal stem cells (hMSCs). Nevertheless, there is a paucity of comparative, molecular-level studies in support of this hypothesis. In the present article, RTPCR was used to examine similarities and differences in gene expression among MAs, hMSC-derived adipocytes, and subcutaneous adipocytes. While little or no message for lineage-specific markers was detected in undifferentiated hMSCs, the data demonstrate that hMSC-derived adipocytes, MAs, and subcutaneous adipocytes commonly express mRNA encoding for adipogenic transcription factors (PPARgamma2, C/EBPalpha, and SREBP1), adipokines (adipsin, leptin, APM1, and angiotensinogen), and lipid-metabolizing agents (aP2 and LPL), among other genes. None of the cell populations examined expressed a detectable level of the brown fat marker UCP1. This suggests highly similar gene expression between human subcutaneous and MAs, not previously substantiated to this degree. Coupled with the hMSC-derived adipocyte analysis, these data provide a framework ultimately for characterizing MAs and identifying their origin and function.

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Marrow adipose tissue: Response to erythropoiesis

Cited by 42 publications

References 20 publications

Chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats

Chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats

Stromal cell associated haemopoiesis

Characterizing medullary and human mesenchymal stem cell‐derived adipocytes

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