“…During the period 1939 to 1950, Dominquez in the United States made significant contributions with articles on the pharmacokinetics of creatinine, mannitol, xylose and galactose (Dominguez, 1934;Dominguez and Pomerene, 1934;Dominguez et al, 1935;Pomerene, 1944, 1945a,b;Dominguez et al, 1947a and1947b;Dominguez, 1950). He introduced the concept of the volume of distribution and defined it as the hypothetical volume of body fluid dissolving the substance at the same concentration as that in plasma (Dominguez, 1934). Dominguez was also the first to derive and apply Eqn (3) to estimate the rate of absorption of a substance as a function of time.…”