Studies of polyarthritis caused by mycoplasma arthritidis in rats III. Histopathological findings

Hermanns, W.; Schulz, L. Cl.; Kirchhoff, H; Heitmann, Jan

doi:10.1016/s0174-3031(83)80125-5

Cited by 5 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chronic phase was characterized by destruction of cartilage and bone, ankylosis, and chronic inflammation. In about 25% of the joints investigated, acute recurrences were observed (18). Histological signs of arthritis were observed in LEW rats but not in BUF, WKY, or OM rats.…”

Section: Discussionmentioning

confidence: 92%

“…Histological examinations were performed on nine LEW, nine OM, three WKY, and three BUF rats. Shoulder, elbow, carpus, stifle, and tarsus samples from each animal were prepared as described elsewhere (18).…”

Section: Methodsmentioning

confidence: 99%

“…Reisolation of mycoplasmas and histology. All nine LEW rats histologically investigated showed the characteristic signs of mycoplasmal arthritis (18). Of the 45 joints investigated, 12 were affected.…”

Section: -mentioning

confidence: 97%

See 2 more Smart Citations

Strain differences in sensitivity of rats to Mycoplasma arthritidis ISR 1 infection are under multiple gene control

et al. 1990

View full text Add to dashboard Cite

At least 5 female rats from each of 24 inbred (ACI, AS, BDIX, BH, BN, BS, BUF, DA, LE, LEW, MWF, OM, SPRD-Cu3, W-Krypt, and WKY), RTI congenic [BH.lL(LEW), LEW.lA(AVN), LEW.lC(WIST), LEW.lLV3(BH), LEW.lK(SHR), and LEW.1N(BN)], and F1 hybrid [(LEW x BN)F1, (LEW.1W x LEW.1A)F1, and (LEW x LEW.1W)F1] strains, representing eight independent major histocompatibility complex (MHC) haplotypes (a, b, c, dvl, k, 1, n, and u) and five related RTI haplotypes (avi, lvl, 1v3, uv2, and uv3), were inoculated intravenously with Mycoplasma arthritidis, and the severity of the polyarthritis that developed was determined by estimating arthritis scores and weight reductions. The 24 inbred, congenic, and F1 hybrid rat strains differed considerably in their sensitivity to infection with M. arthritidis and in the severity of the polyarthritis that they developed. Statistical evaluation showed that in the acute phase (days 1 to 42 after infection) as well as in the chronic phase (days 39 to 121 after infection) of the disease, the means of the arthritis scores for the strains form a continuous variation without significant interruptions, with the very sensitive LEW rats, the RTI congenic rats on LEW background, the F1 hybrids with LEW, and the MWF, BS, BH, and DA rats on one end and the resistant WKY, BUF, W-Krypt, LE, and OM rats on the other end. A continuous variation was also observed for the means of the growth rates. There were, however, no significant differences between the sensitive and the resistant rat strains in the antibody titers determined by complement fixation test and enzyme immunoassay. Heritabilities of arthritis scores were calculated for all strains (h2 = 0.39 to 0.62), for the RTI congenic strains (h2 = 0.04 to 0.14), and for several strains with identical MHC genes (h2 = 0.61 to 0.93). The results show that non-MHC genes are probably responsible for the sensitivity of rats to infection with M. arthritidis.Animals. Up to 5 female rats from each of 24 inbred (ACI/

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Strain differences in sensitivity of rats to Mycoplasma arthritidis ISR 1 infection are under multiple gene control

et al. 1990

View full text Add to dashboard Cite

show abstract

“…As in our study, they reported that viable mycoplasmas circulating in the blood immediately after the tail vein inoculation were rapidly cleared, leaving only fragmented or dead mycoplasmas trapped with related antibodies detectable in serum samples. Although no longer present in the blood, viable mycoplasmas reportedly have been isolated from a variety of organs, with joint isolates evident up to 200 days following infection (14).…”

Section: Discussionmentioning

confidence: 99%

Circulating and localized immune complexes in experimental mycoplasma-induced arthritis-associated ocular inflammation

1992

View full text Add to dashboard Cite

Ocular deposits of immune complexes are believed to contribute to the anterior segment inflammations observed in association with the human arthritides. Arthritis-related ocular inflammations may be reproduced in animals by infection with certain species of mycoplasma. To evaluate the role of immune complexes in the production of ocular lesions, we studied their involvement in the rodent model of experimental arthritis-associated ocular inflammation induced by Mycoplasma arthritidis. Sprague-Dawley rats were infected with viable concentrates of M. arthritidis and monitored for the production of related circulating and intraocular immune complexes. Circulating immune complexes were monitored by antigen capture systems, and localized intraocular complexes were identified by indirect immunohistochemistry. Polyacrylamide gel immunoblot analysis of captured complexes confirmed the antigen(s) involved as proteins derived from M. arthritidis. Indirect immunofluorescence revealed localized complexes containing mycoplasma antigens within the ciliary-iris vasculature. Concentrations of the generated complexes diminished rapidly over a 30-day period. While complex deposits within ocular tissues could represent a contributing cause to the localized anterior segment inflammation reported in this rodent model, secondary challenge with viable M. arthritidis, which reproduced high concentrations of intraocular and circulating immune complexes, failed to elicit any ocular response.

show abstract

Pathogenetic mechanisms in the Mycoplasma arthritidis polyarthritis of rats

et al. 1989

View full text Add to dashboard Cite

Studies of polyarthritis caused by mycoplasma arthritidis in rats III. Histopathological findings

Cited by 5 publications

References 22 publications

Strain differences in sensitivity of rats to Mycoplasma arthritidis ISR 1 infection are under multiple gene control

Strain differences in sensitivity of rats to Mycoplasma arthritidis ISR 1 infection are under multiple gene control

Circulating and localized immune complexes in experimental mycoplasma-induced arthritis-associated ocular inflammation

Pathogenetic mechanisms in the Mycoplasma arthritidis polyarthritis of rats

Contact Info

Product

Resources

About