Pathogenetic mechanisms in the Mycoplasma arthritidis polyarthritis of rats

Kirchhoff, H; Binder, Alfred; Runge, Martin; Meier, Beate; Jacobs, Ruschca; Busche, K

doi:10.1007/bf00271879

Cited by 28 publications

(10 citation statements)

References 6 publications

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“…Importantly, the injection of isolated membranes from M. arthritidis resulted in toxicities in animals similar to those found in rheumatic disease [82]. This might be related to correspondence in the antigenic epitopes of chondrocytes and M. arthritidis membrane components.…”

Section: Rheumatic Diseasesmentioning

confidence: 78%

Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments

Nicolson¹

2019

IJCM

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The presence of pathogenic mycoplasmas in various chronic illnesses and their successful suppression using conventional and integrative medicine approaches are reviewed. Evidence gathered over the last three decades has demonstrated the presence of pathogenic mycoplasma species in the blood, body fluids and tissues from patients with a variety of chronic clinical conditions: atypical pneumonia, asthma and other respiratory conditions; oral cavity infections; urogenital conditions; neurodegenerative and neurobehavioral diseases; autoimmune diseases; immunosuppressive diseases; inflammatory diseases; and illnesses and syndromes of unknown origin, such as fatiguing illnesses. Only recently have these small intracellular bacteria received attention as possible causative agents, cofactors or opportunistic infections or co-infections in these and other conditions. Their clinical management is often inadequate, primarily because of missed diagnosis, underand inadequate treatment and the presence of persister or dormant microorganisms due to biofilm, resistence and other mechanisms. Pathogenic Mycoplasma species infections have been suppressed slowly by anti-microbial and integrative treatments, resulting in gradual reductions in morbidity, but not in every patient. Even if mycoplasmas are not a cause or an initial trigger for many chronic illnesses, they appear to play important roles in the inception, progression, morbidity and relapse of chronic illnesses in rather large patient subsets. Ignoring such infections can result in failure to achieve eventual patient recovery, even with application of potentially curative treatments.

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Section: Rheumatic Diseasesmentioning

confidence: 78%

Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments

Nicolson¹

2019

IJCM

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“…The fact that P-140 was recovered from synovia suggests that this anatomical site or environment is a suitable biological niche for the bacteria. Several other studies have shown that the destruction of epithelial cells during arthritis; promotes the growth of mycoplasmas by the release of substances, which can be used as nutrients by mycoplasmas, and it creates the basis for further damage to the joint [25]. Washburn et al .…”

Section: Discussionmentioning

confidence: 99%

“…and Kirchhoff et al . showed that microbial products or the mere cellular lesion could stimulate the secretion of cytokines, which play an important role in the development of arthritis [18,25]. …”

Section: Discussionmentioning

confidence: 99%

Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

Rivera

Yáñez

León-Tello

et al. 2002

BMC Musculoskelet Disord

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Background: Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints.

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“…Pyrogenic exotoxins stimulate macrophages to produce mediators such as IL-1 and TNF and production of these mediators was induced by products of mycoplasma [17][18][19]. Mycoplasmas produce haemolysins and cytotoxic substances that affect rat, mouse and chicken embryos and foetal rat skin fibroblasts [20][21][22]. These toxic materials might act on cells of the immune system to induce cytokines such as macrophage deactivating factor (MDF) or TGF-/3 resulting in suppression of macrophage antimicrobial activity that would account for the survival of mycoplasma.…”

Section: Discussionmentioning

confidence: 99%

The effect of Mycoplasma arthritidis infection on the kinetics of colloidal carbon clearance in mice

Kaklamani

1993

FEMS Immunology and Medical Microbiology

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The activity of phagocytes from A/J mice was estimated by the carbon clearance test following injection of Mycoplasma arthritidis. Phagocytic activity was significantly depressed 12 h post-infection (P = 0.001) and returned to normal values at 24 h. For animals examined 2 and 7 days post-infection, the overall phagocytic activity increased significantly (P < 10(-4). Phagocytic activity gradually decreased and returned to that of the control group by the end of the fourth week. The relative weights of liver and spleen were significantly increased from the 2nd day post infection (P = 0.0028 and P = 0.0014 respectively) and remained increased until the end of the experiment. The early depressive effect on phagocytic activity may be related to superantigen activity with the production of mediators such as macrophage deactivating factor. The later expansion of the macrophage population might bring about the stimulation of autoreactive clones of T and B cells and be responsible for the chronic arthritis that developed in the mycoplasma treated mice.

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Pathogenetic mechanisms in the Mycoplasma arthritidis polyarthritis of rats

Cited by 28 publications

References 6 publications

Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments

Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments

Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

The effect of Mycoplasma arthritidis infection on the kinetics of colloidal carbon clearance in mice

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