Studies of Alkalosis. Ii. Electrolyte Abnormalities in Alkalosis Resulting From Pyloric Obstruction 1

Metabolic and Renal Studies in Chronic Potassium Depletion Resulting From Overuse of Laxatives 12

“…The important contribution of renal "leakage" of potassium to the development of potassium depletion in man has been emphasized (26,27 (29).…”

Studies of Alkalosis. I. Renal Function During and Following Alkalosis Resulting From Pyloric Obstruction 1

“…Hence, there is depletion not only of chloride but also of water, sodium and potassium (16,26). All of the patients here reported fell into this category.…”

“…It may be inferred that they were also present in the fifth (Case 4), since the first carbon dioxide content of the serum was measured two days after intensive administration of parenteral saline. The biochemical abnormalities and their relationship to the disturbed renal function are discussed at greater length in another report (16).…”

“…Chemical methods employed in analysis of the blood and urine, exclusive of those employed in estimating the renal function, are described in another report (16). Clearance of inulin, mannitol and para-aminohippuric acid, and maximal tubular excretory capacity of para-aminohippuric acid were determined essentially according to Goldring and Chasis (17).…”

Renal function and the excretion of potassium in acute alkalosis

“…More recently, Burnett et al (1950) have also found increased rates of potassium excretion and high potassium clearances in a group of similar patients. The effect of alkalosis on potassium excretion is difficult to assess in pyloric stenosis as this condition is complicated by other factors which affect the excretion of this ion, such as starvation (Benedict, 1915), dehydration (Mudge, Foulkes & Gilman, 1950) and a low filtration rate (McCance & Widdowson, 1937).…”