Studies of Alkalosis. I. Renal Function During and Following Alkalosis Resulting From Pyloric Obstruction 1

Intracellular Cation Exchanges in Metabolic Alkalosis 1

“…These observations have suggested that both low potassium intake and hyperadrenocortical function are implicated in the etiology of this disturbance. In addition to these two etiological factors a third has been postulated, namely, impaired renal conservation of the potassium ion (12).…”

Studies of Alkalosis. Ii. Electrolyte Abnormalities in Alkalosis Resulting From Pyloric Obstruction 1

“…He was first seen after a prolonged period of continuous vomiting and alkali ingestion ( . -i-i-- (5). On admission the clinical and chemical findings resembled those of Case 1.…”

“…Urine was collected by an indwelling catheter and the bladder rinsed with distilled water at the end of each period. Glomerular filtration rate was measured by inulin clearance in Case 2 (13), and by endogenous "creatinine" in Case 4 (9 (5,14). He was first seen after a prolonged period of continuous vomiting and alkali ingestion ( .…”

“…This report describes abnormalities of water and electrolyte metabolism, and discusses some mechanisms of their production, in patients with alkalosis resulting primarily from loss of upper gastrointestinal contents. Renal insufficiency, which occurred in a number of them, was the subject of a previous report (5).…”