Renal function and the excretion of potassium in acute alkalosis

Franglen, Geoffrey; McGarry, Eleanor E.; Spencer, Andrew

doi:10.1113/jphysiol.1953.sp004928

Cited by 16 publications

(3 citation statements)

References 17 publications

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“…A LTHOUGH THE MORE RECENT DATA derived from micropuncture studies (I) seem to indicate that K+ reabsorption by the proximal tubule is not as complete as was initially supposed (2), it is generally assumed that distal tubular secretion plays a major role in K+ excretion by the kidney (3)(4)(5)(6). It has further been repeatedly demonstrated that K+ excretion is strongly influenced by blood pH changes (3,(7)(8)(9)(10). This phenomenon was explained by the competitive relationship between distal cellular K+ and H+ secretion in exchange for urinary Na+ ions (I I, I 2).…”

mentioning

confidence: 99%

Effects of blood pH changes on potassium excretion in the dog

Toussaint

Vereerstraeten

1962

American Journal of Physiology-Legacy Content

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K+ excretion rate was measured at normal as well as at rising plasma K+ concentration in intact, in K-depleted, and in acetazolamide-treated dogs submitted to acute blood pH changes. The results indicate that, for any given value of glomerular filtration rate, K+ excretion rate is determined by at least three factors: 1) plasma K+ concentration, 2) blood pH level, and 3) presumably, the H+ gradient across the luminal border of the distal tubule. The data further suggest that most of the filtered K+ is reabsorbed by the proximal tubule, even in conditions of high filtered loads.

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confidence: 99%

Effects of blood pH changes on potassium excretion in the dog

Toussaint

Vereerstraeten

1962

American Journal of Physiology-Legacy Content

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“…Plasma HCO 3 Ϫ concentration has a profound effect on renal K ϩ handling, with metabolic alkalosis increasing excretion (27,75) and acidosis decreasing excretion (103). Distal micropuncture by Malnic et al (60) localized much of this effect to the accessible DCT.…”

Section: Distal Nephron: K ؉ Secretionmentioning

confidence: 99%

Mathematical models of renal fluid and electrolyte transport: acknowledging our uncertainty

Weinstein

2003

American Journal of Physiology-Renal Physiology

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Mathematical models of renal tubular function, with detail at the cellular level, have been developed for most nephron segments, and these have generally been successful at capturing the overall bookkeeping of solute and water transport. Nevertheless, considerable uncertainty remains about important transport events along the nephron. The examples presented include the role of proximal tubule tight junctions in water transport and in regulation of Na(+) transport, the mechanism by which axial flow in proximal tubule modulates solute reabsorption, the effect of formate on proximal Cl(-) transport, the assessment of potassium transport along collecting duct segments inaccessible to micropuncture, the assignment of pathways for peritubular Cl(-) exit in outer medullary collecting duct, and the interaction of carbonic anhydrase-sensitive and -insensitive pathways for base exit from inner medullary collecting duct. Some of these uncertainties have had intense experimental interest well before they were cast as modeling problems. Indeed, many of the renal tubular models have been developed based on data acquired over two or three decades. Nevertheless, some uncertainties have been delineated as the result of model exploration and represent communications from the modelers back to the experimental community that certain issues should not be considered closed. With respect to model refinement, incorporating more biophysical detail about individual transporters will certainly enhance model reliability, but ultimate confidence in tubular models will still be contingent on experimental development of critical information at the tubular level.

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“…K daily and the normal individual who is in K balance excretes a similar quantity of this ion in the urine. In a person with normal renal function this amounts to about 10% of the filtered load of K. I n certain circumstances (McCance & Widdowson, 1937;Berliner, Kennedy & Hilton, 1950;Berliner & Kennedy, 1951;Mudge, Foulks & Gilman, 1948; Franglen, McGarry & Spencer, 1953) the amount of K in the urine can be shown to exceed the quantity filtered by the glomeruli, and it is therefore obvious that the renal tubules are capable of secreting K. A great deal of information has accumulated (Berliner, 1960) which suggests that the filtered K is almost entirely reabsorbed in the upper portion of the renal tubule, that which appears in the urine being secreted into the tubular fluid at a more distal point in the nephron.…”

Section: Symposium Proceedings 1965mentioning

confidence: 99%

Renal mechanisms of potassium depletion

Lambie

1965

Proc. Nutr. Soc.

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Renal function and the excretion of potassium in acute alkalosis

Cited by 16 publications

References 17 publications

Effects of blood pH changes on potassium excretion in the dog

Effects of blood pH changes on potassium excretion in the dog

Mathematical models of renal fluid and electrolyte transport: acknowledging our uncertainty

Renal mechanisms of potassium depletion

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