“…]'*rediction of clinically manifest penicillin allergy has been attempted by studies for skin-sensitizing antibodies. In a few investigations (74,86,87) it has seemed possible to rule out immediate reactions, in particular anaphylactic, by investigation for skin-sensitizing antibody using penicillin and penicilloyl-polylysine. But it is doubtful whether these findings can be confirmed and Avhether a demonstration of skin-sensitizing antibodies to penicillin derivatives is invariably tantamount to clinically manifest penicillin allergy.…”