Studies in Iron Transportation and Metabolism. Iv. Observations on the Absorption of Iron From the Gastro-Intestinal Tract 12

Moore, Carl V.; Arrowsmith, Wm. R.; Welch, Jo; Minnich, Virginia

doi:10.1172/jci101069

Cited by 95 publications

(23 citation statements)

References 37 publications

(52 reference statements)

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“…The difference between the mean absorption with normal gastric juice in this group of six patients with achylia gastrica and the absorption of bread iron alone in control subjects was not statistically significant. food (1-3, 7, 15, 16) but plays no part in the absorption of larger doses of inorganic iron salts (8)(9)(10)(11) or of hemoglobin iron (12,13). The only work at variance with the postulate that gastric secretion plays a role in the absorption of food iron is the study of Pirzio-Biroli, Bothwell, and Finch (14), who observed that four subjects with achylia gastrica and a larger group of control subjects both absorbed 5.3% of iron from a standard meal.…”

Section: Methodsmentioning

confidence: 99%

“…Early clinical studies in which iron absorption was measured by the rate of hemoglobin regeneration in iron-deficient subjects suggested that gastric acidity plays a role in the absorption of food iron (1-3), therapeutic doses of inorganic iron salts, and ferrum reductum (4)(5)(6). Defective absorption of dietary iron has been demonstrated in achlorhydric subjects by a chemical balance technique (7), but several workers using serum iron tolerance curves as an index of absorption have reported that achlorhydria does not reduce the assimilation of large doses of inorganic iron salts (8)(9)(10). More recent data obtained by isotopic methods are conflicting, and in many instances the number of observations is too few to support firm conclusions.…”

mentioning

confidence: 99%

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The Effect of Achylia Gastrica on Iron Absorption*

Cook¹,

Brown²,

Valberg³

1964

J. Clin. Invest.

103

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

The Effect of Achylia Gastrica on Iron Absorption*

Cook¹,

Brown²,

Valberg³

1964

J. Clin. Invest.

103

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“…It is well recognized that patients with iron deficiency anemia absorb iron at an accelerated rate (40 to 42) but the increase in plasma iron following its ingestion may be insignificant or quite pronounced (40). In the case of iron deficiency anemia in which the studies illustrated in Figures 5 and 6 Figure 1).…”

Section: Chemical Studiesmentioning

confidence: 99%

The Anemia of Infection. I. Hypoferremia, Hypercupremia, and Alterations in Porphyrin Metabolism in Patients 1

Cartwright¹,

Lauritsen²,

Jones³

et al. 1946

J. Clin. Invest.

148

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“…The subject has been reviewed by a number of investigators (12,14,17,18). Changes in plasma iron as an index of absorption have been studied by these workers.…”

Section: Plasma and Serum Ironmentioning

confidence: 99%

Radioactive Iron Absorption by Gastro-Intestinal Tract

Hahn

Bale

Ross

et al. 1943

Journal of Experimental Medicine

320

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Iron absorption is a function of the gastro-intestinal mucosal epithelium. The normal non-anemic dog absorbs little iron but chronic anemia due to blood loss brings about considerable absorption—perhaps 5 to 15 times normal. In general the same differences are observed in man (1). Sudden change from normal to severe anemia within 24 hours does not significantly increase iron absorption. As the days pass new hemoglobin is formed. The body iron stores are depleted and within 7 days iron absorption is active, even when the red cell hematocrit is rising. Anoxemia of 50 per cent normal oxygen concentration for 48 hours does not significantly enhance iron absorption. In this respect it resembles acute anemia. Ordinary doses of iron given 1 to 6 hours before radio-iron will cause some "mucosa block"—that is an intake of radio-iron less than anticipated. Many variables which modify peristalsis come into this reaction. Iron given by vein some days before the dose of radio-iron does not appear to inhibit iron absorption. Plasma radio-iron absorption curves vary greatly. The curves may show sharp peaks in 1 to 2 hours when the iron is given in an empty stomach but after 6 hours when the radio-iron is given with food. Duration time of curves also varies widely, the plasma iron returning to normal in 6 to 12 hours. Gastric, duodenal, or jejunal pouches all show very active absorption of iron. The plasma concentration peak may reach a maximum before the solution of iron is removed from the gastric pouch—another example of "mucosa block." Absorption and distribution of radio-iron in the body of growing pups give very suggestive experimental data. The spleen, heart, upper gastro-intestinal tract, marrow, and pancreas show more radio-iron than was expected. The term "physiological saturation" with iron may be applied to the gastro-intestinal mucosal epithelium and explain one phase of acceptance or refusal of ingested iron. Desaturation is a matter of days not hours, whereas saturation may take place within 1 to 2 hours. We believe this change is a part of the complex protein metabolism of the cell.

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Studies in Iron Transportation and Metabolism. Iv. Observations on the Absorption of Iron From the Gastro-Intestinal Tract 12

Cited by 95 publications

References 37 publications

The Effect of Achylia Gastrica on Iron Absorption*

The Effect of Achylia Gastrica on Iron Absorption*

The Anemia of Infection. I. Hypoferremia, Hypercupremia, and Alterations in Porphyrin Metabolism in Patients 1

Radioactive Iron Absorption by Gastro-Intestinal Tract

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