Radioactive Iron Absorption by Gastro-Intestinal Tract

Hahn, P. F.; Bale, William F.; Ross, Joseph F.; Balfour, William M.; Whipple, G. H.

doi:10.1084/jem.78.3.169

Cited by 320 publications

(48 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…But how does the body "know" how much iron to absorb? Over the past 60 years attempts have been made to explain the regulation of iron absorption through the existence of a "mucosal block" [3], a flawed concept based on flawed data, as I have described in detail elsewhere [4]. What the experimental data actually show is not the existence of a "blocking" of iron absorption after an initial dose of iron has been given, but rather "mucosal intelligence".…”

Section: The Fundamentals Of Iron Metabolismmentioning

confidence: 99%

Iron storage disease: Facts, fiction and progress

Beutler

2007

Blood Cells, Molecules, and Diseases

View full text Add to dashboard Cite

There are many forms of iron storage disease, some hereditary and some acquired. The most common of the hereditary forms is HFE-associated hemochromatosis, and it is this disorder that is the main focus of this presentation. The body iron content is regulated by controlling absorption, and studies in the past decade have clarified, in part, how this regulation functions. A 25 amino acid peptide hepcidin is upregulated by iron and by inflammation, and it inhibits iron absorption and traps iron in macrophages by binding to and causing degradation of the iron transport protein ferroportin. Most forms of hemochromatosis results from dysregulation of hepcidin or defects of hepcidin or ferroportin themselves.Hereditary hemochromatosis was once considered to be very rare, but in the 1970s and 1980s, with the introduction of better diagnostic tests, it became to be considered the most common disease of Europeans. Controlled epidemiologic studies carried out in the last decade have shown, however, the disease itself actually is rare, and it is only the genotype and associated biochemical changes that are common. We do not understand why only a few homozygotes develop severe disease. It now seems unlikely that there are important modifying genes, and although alcohol is known to have some effect, excess drinking probably plays only a modest role in determining the hemochromatosis phenotype.Hereditary hemochromatosis is readily treated by phlebotomy. Secondary forms of the disease require chelation therapy, and the recent introduction of effective oral chelating agents is an important step forward in treating patients with disorders in which iron overload often proves to be fatal, such as thalassemia, myelodysplastic anemias, and dyserythropoietic anemias.While much has been learned about the regulation of iron homeostasis in the past decade, many mysteries remain and represent challenges that will keep us occupied for years to come.It is a great honor for me to present this lecture in memory of my good friend Bracha Ramot. It is because this lecture is in honor of Bracha that I do not feel the least bit uncomfortable speaking about iron storage diseases in a symposium entitled "Genomics and Molecular Biology of Hematopoietic Malignancies". I know that had it been possible to ask her whether this might be appropriate Bracha would have said: "Of course, Ernie. Talk about whatever you want to". That was her way. And, of course, Bracha was no stranger to iron metabolism. She was scientifically broad, a Renaissance hematologist. A MEDLINE search reveals 261 publications by Bracha and eight of those deal with iron --iron in thalassemia, iron in sideroblastic anemia, and iron in iron deficiency anemia.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable...

show abstract

Section: The Fundamentals Of Iron Metabolismmentioning

confidence: 99%

Iron storage disease: Facts, fiction and progress

Beutler

2007

Blood Cells, Molecules, and Diseases

View full text Add to dashboard Cite

show abstract

“…No despontar do século XX, aprofundam-se os estudos sobre o metabolismo do ferro, e nos anos 40 Hahn e colaboradores, mediante estudos com isótopos radioativos do ferro, descrevem um fenômeno de supressão de absorção do mineral em cães (Hahn et al, 1943). Na década de 1980, o fenômeno do bloqueio da mucosa é confirmado em seres humanos.…”

Section: Históricounclassified

Epidemiologia nutricional

Kac¹,

Sichieri²,

Gigante³

2007

View full text Add to dashboard Cite

show abstract

“…The limited effectiveness of relatively large doses of oral iron in stimulating hepatic ferritin synthesis doubtless depends on the small amount of iron normally transported across the intestinal mucosa and into the circulation. Nevertheless, it is apparent that sufficient iron reaches the liver to double or triple the resting incorporation rate (15). The elevenfold increase in incorporation of isotope into liver ferritin when iron is administered intraperitoneally demonstrates the effect of iron in initiating the formation of apoferritin when it is able to reach the hepatic cells in sufficient amounts.…”

Section: Discussionmentioning

confidence: 99%