The Effect of Achylia Gastrica on Iron Absorption*

Food Iron Absorption Measured by an Extrinsic Tag

“…When extrinsic tag was given after the test meal prepared in the normal manner (study 13), the E: I ratio was 1.28. With earlier addition of the extrinsic tag and complete homogenization of the meal (study 14), the ratio was pose (26)(27)(28)(29)(30)(31)(32)(33), any implication that the results provide a valid measure of iron absorption from the meal has been carefully avoided. Schulz and Smith (4) compared the absorption of intrinsic and extrinsic iron, reporting a mean absorption of 9.1% in 10 children given milk labeled in vivo as compared with the mean of 10.6% in 10 children given a test dose of milk to which radioiron had been added.…”

Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

“…5 Impaired iron absorption in PA is corrected by normal, but not by neutralized, gastric juice-indicating that lack of gastric acidity is the key factor in abnormal iron absorption. 33 Other studies have also shown that iron absorption is heavily dependent on normal gastric secretion and acidity for solubilizing and reducing dietary iron. 34,35 If autoimmune atrophic gastritis impairs both food iron and food Cbl absorption, what are the factors determining its clinical presentation in the form of microcytic IDA or macrocytic megaloblastic anemia?…”

Malabsorption of hemoglobin iron in pernicious anemia: correction with intrinsic factor—containing substances

“…Jacobs, Bothwell, and Charlton (32) studied patients with PA in remission and found that HO enhanced the absorption of ferric chloride but not ferrous ascorbate or hemoglobin iron. Cook, Brown, and Valberg (33) found that achlorhydric patients absorbed 1/2 the expected amount of inorganic iron given with bread; the malabsorption was corrected by the addition of gastric juice but not as well by neutralized gastric juice. The presence of a gastric protein with ability to affect inorganic iron absorption has been suggested (17-34).…”