Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

Hershko, Chaim; Ronson, Aaron; Souroujon, Moshe; Maschler, Itzhak; Heyd, Judith; Patz, Julian

doi:10.1182/blood-2005-09-3534

Cited by 193 publications

(182 citation statements)

References 33 publications

(38 reference statements)

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“…Scientists have focused on the essential information that belongs to the bacterium for the last 20 years [8,14,17] . There are evidences on the fact that helicobacter infections cause iron deficiency [11][12][13][14][15][16] . The explanation most commonly offered for this relationship is based upon the development of H. pylori-associated chronic pangastritis with resultant achlorhydria and reduced ascorbic acid secretion leading to reduced intestinal iron absorption.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are many studies [11][12][13][14][15][16] on helicobacter infections and iron deficiency in human medicine, it has not been completely revealed with what mechanisms this condition occurs in humans with helicobacter infections. The explanation most commonly offered for this relationship is based upon the development of H. pylori-associated chronic pangastritis with resultant achlorhydria and reduced ascorbic acid secretion leading to reduced intestinal iron absorption.…”

Section: Introductionmentioning

confidence: 99%

“…In iron deficiency anemia, serum ferritin level decreases, and it increases in chronic disease anemia. Although there are many studies [11,13,14] and discussions on it in human medicine, there are no authentic studies about it in veterinary medicine as far as our knowledge. Our study aims to reveal the relationship between helicobacter infections in dogs and iron deficiency anemia.…”

Section: Introductionmentioning

confidence: 99%

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Helikobakter Enfeksiyonlu Köpeklerde Demir Yetmezliği Anemisinin Belirlenmesi

Yücel¹,

Dalğın²,

Söğüt³

2015

Kafkas Univ Vet Fak Derg

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Many studies demonstrated that Helicobacter infections in humans affects iron metabolism and decreases ferritin level resulting with iron deficiency anemia. The aim of this study is the investigation of a correlation between Helicobacter infection and iron deficiency anemia in dogs. The material of the study consisted of 42 Helicobacter (+) (determined with polymerase chain reaction-PCR-following upper gastrointestinal system endoscopy) dogs (Group I) (n=42) referred with vomiting after feeding, anorexia and epigastric pain in the abdominal palpation, and 21 (Group II) (n=21) dogs negative for Helicobacter with PCR and in the routine clinical examinations. Grup I were given therapy against Helicobacter gastritis for 21 days. Blood specimen were obtained from Group I at 0. and 21. days and Group II at 0. day for blood count and ferritin levels. Iron deficiency anemia was observed in 28 dogs of 42 (66.6%) infected with Helicobacter. In conclusion, iron deficiency anemia can be a probable evidence in frequently diagnosed Helicobacter infections in dogs and must be considered in the diagnostic and therapeutic plan. This is also the first study investigating iron deficiency anemia in Helicobacter infections of dogs as far as our knowledge. Keywords: Helicobacter, Dog, Iron deficiency, Anemia, Serum ferritin Helikobakter Enfeksiyonlu Köpeklerde Demir Yetmezliği Anemisinin Belirlenmesi ÖzetHelikobakter enfeksiyonunun insanlarda demir metabolizmasını etkileyerek ferritin seviyesinin düşüşüne neden olduğu ve demir eksikliği anemisi oluşturduğu çeşitli çalışmalarla ortaya konulmuştur. Bu çalışmanın amacı, köpeklerde helikobakter enfeksiyonu ile demir eksikliği anemisi arasında bir ilişki olup olmadığının araştırılmasıdır. Çalışma materyalini, yemeyi takiben kusma, iştahsızlık ve abdominal palpasyonda epigastrik ağrı şikayeti ile getirilen ve üst gastro intestinal sistem endoskopisi sonucu polimeraz zincir reaksiyonu (PZR) ile helikobakter (+) olduğu saptanan 42 adet (Grup I) (n=42) köpek ve rutin klinik muayeneleri ve PZR'yle pozitiflik saptanmayan 21 adet (Grup II) (n=21) köpek oluşturmuştur. Grup I, Helikobakter gastritisi yönünden 21 gün süreyle tedavi edildi. Grup I'den 0. ve 21. günler, Grup II'den 0.gün kan sayımı ve serum ferritin bakıldı. Helikobakter ile enfekte 42 köpeğin 28'inde (%66.6) demir eksikliği anemisi saptandı. Sonuç olarak, köpeklerde sıklıkla gözlenen helikobakter enfeksiyonlarında demir eksikliği anemisinin kuvvetle muhtemel bir bulgu olabileceği ve hastanın teşhis ve tedavi şeması dahilinde göz önüne alınması gerekliliği ortaya konmuştur. Bu aynı zamanda, araştırmalarımız çerçevesinde köpeklerde Helikobakter enfeksiyonlarında demir eksikliği anemisini inceleyen ilk araştırmadır.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Helikobakter Enfeksiyonlu Köpeklerde Demir Yetmezliği Anemisinin Belirlenmesi

Yücel¹,

Dalğın²,

Söğüt³

2015

Kafkas Univ Vet Fak Derg

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“…D'après l'étude de Hershko et al, chez des patients ayant une maladie de Biermer, le jeune âge et le sexe féminin semblent également favoriser la survenue d'une carence martiale [38,62]. De même, le régime végétalien et la gastrite atrophique sont souvent associés à une carence martiale.…”

Section: Etiologie De La Carence En Vitamine B12unclassified

Carence en vitamine B12 (1^repartie) : mise au point

Loup-Leuciuc

Loup

Lombardi

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 12 mai 2011, accepté le 24 juin 2011) Mots clés : vitamine B12 / métabolisme / carence / manifestationsRésumé -Classiquement, la carence en vitamine B12 s'accompagne d'une anémie mégaloblastique, de manifestations neuropsychiatriques et d'une glossite de Hunter. En réalité, les manifestations sont protéiformes et chacune d'elles peut rester longtemps isolée. Les manifestations stomatologiques, souvent discrètes, peuvent précéder de plusieurs années les autres manifestations. Elles constituent parfois un signe d'appel pour le dépistage précoce de cette carence. Depuis une bonne dizaine d'années, la conception de la physiopathologie de la carence en vitamine B12 a beaucoup évolué : on a identifié le syndrome de non-dissociation de la vitamine B12 des protéines porteuses qui constitue maintenant la principale cause de carence en vitamine B12 et il a été démontré qu'on peut effectuer un traitement de la carence per os. Key words: vitamin B12 / metabolism / deficiency / manifestationsAbstract -Vitamin B12 deficency. Part 1: update and littérature review. Vitamin B12 deficiency is classically accompanied by a megaloblastic anemia, neuropsychiatric disorders and an Hunter glossitis. Clinical manifestations are indeed polymorphic and each may remain the only one for a long period of time. Stomatological manifestations, often mild, may precede the others of many years. They sometimes are the first sign to early diagnose this deficiency. Since the last ten years, the physiopathology of vitamin B12 deficiency has considerably changed. In fact, nowadays, the main cause is the syndrome of food cobalamin malabsorption. It has also been demonstrated that the deficiency may now treated by an oral cobalamin therapy.La vitamine B12 est une vitamine hydrosoluble qui a une structure chimique proche de celle de l'hème avec un atome central constitué par du cobalt, d'où le nom de cobalamine (Fig. 1).Elle existe sous plusieurs formes regroupées dans la famille des cobalamines : cyanocobalamine, hydroxocobalamine, mé-thylcobalamine et adénosylcobalamine. La cyanocobalamine et l'hydroxocobalamine sont les seules formes stables. On peut considérer que les recherches sur la vitamine B12 ont commencé au XIX e siècle avec la description d'une anémie mortelle, l'anémie pernicieuse, par Thomas Addison et Michael Anton Biermer. Vers 1920, George Whipple, George Minot et William Murphy, tous les trois Prix Nobel de médecine en 1934, ont démontré que des extraits de foie sous forme de compléments alimentaires étaient susceptibles de corriger certaines anémies. On en a conclu que les extraits de foie contenaient le facteur extrinsèque, en réalité de la vitamine

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“…Primary immune thrombocytopenia [26][27][28][29][30][31][32][33]36,37,40,43,48,62 Low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma [50][51][52][53]62 Controversial hematologic associations with H. pylori infection Pernicious anemia [54][55][56] Monoclonal gammopathy of undetermined significance 57,58 Myelodysplastic syndrome 59 …”

mentioning

confidence: 99%