Structuring a Multicriteria Model to Optimize the Profitability of a Clinical Laboratory

Capistrano, João Ricardo; Pinheiro, Plácido Rogério; Júnior, Jorcelan Gonçalves da Silva; Nogueira, Plínio de Sousa

doi:10.1007/978-3-030-31362-3_6

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Making everyday decisions involving everyday life becomes more complicated, as it is necessary to solve the problem, taking into account different perspectives and evaluating according to the specific form of the problem and, thus, a set of alternative solutions can be considered multiple criteria conflicting with each other ( [18] and [19]). This line of reasoning [20,21] confirms that before choosing two alternative actions, the choice of a multi-criteria decision problem is motivated by the desire to satisfy multiple, often conflicting objectives.…”

Section: Support Multi-criteria Decisionmentioning

confidence: 87%

Using the Multi-Criteria Model for Optimization of Operational Routes of Thermal Power Plants

Moraes¹,

Pinheiro

Rolim³

et al. 2021

Energies

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The constant problems evidenced in the Brazilian hydrological scenario, where the source of hydraulic potential corresponds to about 63.9% of the energy matrix, coupled with the exponential growth in the supply of renewable energy, corroborates the importance of thermal power generation as the basis of Brazilian’s energy matrix. With the operation of thermal power plants, which characteristically involve a large number of systems, subsystems, and auxiliary equipment, there is a high demand for the use of methodologies for monitoring and controlling processes, analyzing failures, and implementing improvements and actions that increase the reliability and, consequently, reduce the failure rate. In this context, decision-making about prioritizing criticality for operational monitoring of an asset’s components, from the perspective of operation and maintenance planning and based on reliability-centered maintenance (RCM) concepts, can be considered a complex task. Given this, the research seeks to demonstrate how the “Measuring Attractiveness by a Category Based Evaluation Technique (MACBETH)” method can be applied to the development of a multiple criteria model to support decision making in ordering the criticality of systems in operational inspection routes of thermal power plants, to propose new routines execution methodologies, aiming at increasing the productivity of the operation team. According to the results of the judgment matrix, the ordering proposal allowed a strategy for the execution of the current operational routes, redefining criticality, periodicity, routing, and applied resources, maintaining the reliability of the plant. It limits itself to assessing the criticality of the subsystems and monitored points belonging to the boiler system. These are typical of thermoelectric plants classified within the Rankine thermodynamic cycle and represent a significant part of the evaluation proposal.

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Section: Support Multi-criteria Decisionmentioning

confidence: 87%

Using the Multi-Criteria Model for Optimization of Operational Routes of Thermal Power Plants

Moraes¹,

Pinheiro

Rolim³

et al. 2021

Energies

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“…Figure S13A shows that PBS-treated tumors show almost a slight increase in temperature (less than 37 °C at 5 min) under the same NIR light irradiation, while the maximum temperatures of the tumor in the DiR@Lipo group and combination therapy group after the first irradiation are both about 50 °C, showing a significant rapid temperature rise (Figure S13B,C). To quantify the photothermal effect in vivo, we also calculate the cumulative equivalent minutes at 50 °C (CEM50) 82 for the DiR@Lipo+Laser group and DiR@Lipo+GOx@Lipo+Laser group, which are 4.71 ± 1.37 and 2.63 ± 1.02 min, respectively (Table S2). Although the photothermal curves are similar for the two groups, the former group receives slightly more heat than the latter group.…”

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

Liposomal Glucose Oxidase for Enhanced Photothermal Therapy and Photodynamic Therapy against Breast Tumors

Xia

Cao

et al. 2022

ACS Biomater. Sci. Eng.

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Organic near-infrared fluorescent dye mediated photothermal therapy (PTT) and photodynamic therapy (PDT) suffer from heat shock response, since, heat shock proteins (HSPs) are overexpressed and can repair the proteins damaged by PTT and PDT. Starvation therapy by glucose oxide (GOx) can inhibit the heat shock response by limiting the energy supply. However, the delivery of sufficient and active GOx remains a challenge. To solve this problem, we utilize liposomes as drug carriers and prepare GOx loaded liposome (GOx@Lipo) with a high drug loading content (12.0%) and high enzymatic activity. The successful delivery of GOx shows excellent inhibition of HSPs and enhances PTT and PDT. Additionally, we apply the same liposome formulation to load near-infrared dye 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbo cyanine iodide (DiR) and prepare DiR contained liposomes (DiR@Lipo) for PTT and PDT. The liposomal formulation substantially enhances the PTT and PDT properties of DiR as well as the cellular uptake and tumor accumulation. Finally, the combination therapy shows excellent tumor inhibition on 4T1 tumor-bearing mice. Interestingly, we also find that the starvation therapy can efficiently inhibit tumor metastasis, which is probably due to the immunogenic effect. Our work presents a biocompatible and effective carrier for the combination of starvation therapy and phototherapy, emphasizing the importance of auxiliary starvation therapy against tumor metastasis and offering important guidance for clinical PTT and PDT.

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“…A pesquisa pode ser descrita como um estudo de caso que teve um laboratório de análises clínicas de e permitindo a determinação de seus descritores com base no mapa cognitivo construído [4], [5].…”

Section: Delineando Problemas E Propondo Soluçõesunclassified

Como um modelo de análise multicritério pode otimizar a lucratividade de um laboratório de análises clínicas

Capistrano,

Pinheiro

2022

GEX

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Laboratórios de análises clínicas são negócios complexos e inseridos em um mercado altamente competitivo e inovador. Sendo assim, é crucial que os gestores desse tipo de empresa trabalhem para garantir o aumento de seus lucros sem prejuízo da qualidade dos serviços prestados. Utilizando o método Macbeth de análise multicritério, a pesquisa buscou criar um modelo ordenado de fatores capazes de influenciar significativamente na lucratividade de um laboratório de análises clínicas de pequeno porte.

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Structuring a Multicriteria Model to Optimize the Profitability of a Clinical Laboratory

Cited by 6 publications

References 9 publications

Using the Multi-Criteria Model for Optimization of Operational Routes of Thermal Power Plants

Using the Multi-Criteria Model for Optimization of Operational Routes of Thermal Power Plants

Liposomal Glucose Oxidase for Enhanced Photothermal Therapy and Photodynamic Therapy against Breast Tumors

Como um modelo de análise multicritério pode otimizar a lucratividade de um laboratório de análises clínicas

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