2022
DOI: 10.1038/s41586-022-05040-1
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Structures of the human CST-Polα–primase complex bound to telomere templates

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Cited by 57 publications
(135 citation statements)
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“…Taken together, our results suggest that CST does more than simply promote binding of the DNA template to Polα-primase but also activates it for optimal primase activity. These functional conclusions are in excellent agreement with conclusions based on the recent cryo-EM structure 32 .…”
Section: Cst Activation Of Polα-primasesupporting
confidence: 90%
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“…Taken together, our results suggest that CST does more than simply promote binding of the DNA template to Polα-primase but also activates it for optimal primase activity. These functional conclusions are in excellent agreement with conclusions based on the recent cryo-EM structure 32 .…”
Section: Cst Activation Of Polα-primasesupporting
confidence: 90%
“…In support of this idea, the three genes for the CST components rose to the very top in CRISPR-Cas9 screens for genes important for growth of cancer cell lines with short telomeres 37 . On the basis of the work presented here, the ssDNA-binding site in the CTC1 subunit 19 or Polα-primase-binding sites in all three CST subunits 32,38 seem particularly attractive targets for interfering with telomere end replication.…”
Section: Articlementioning
confidence: 95%
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