Structure of the mouse thioredoxin-encoding gene and its processed pseudogene

Matsui, Masanao; Taniguchi, Yuji; Hirota, Kiichi; Taketo, Makoto Mark; Yodoi, Junji

doi:10.1016/0378-1119(94)00707-y

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…The sequence from position Ϫ452 to Ϫ420 bp of the human thioredoxin promoter is highly homologous to that from position Ϫ607 to Ϫ575 bp of the mouse thioredoxin gene (15), indicating that the sequence in the thioredoxin promoter is conserved in both the human and mouse thioredoxin genes. We previously reported an oxidative responsive element (ORE), which is the sequence from Ϫ953 to Ϫ930 bp and mediates the stress response of hydrogen peroxide (14).…”

Section: Discussionmentioning

confidence: 88%

Hemin-induced Activation of the Thioredoxin Gene by Nrf2

Kim

Masutani

Yamaguchi

et al. 2001

Journal of Biological Chemistry

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274

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Section: Discussionmentioning

confidence: 88%

Hemin-induced Activation of the Thioredoxin Gene by Nrf2

Kim

Masutani

Yamaguchi

et al. 2001

Journal of Biological Chemistry

Self Cite

274

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“…Regarding the coding region of Txn, the nucleotide sequences were identical in the three strains studied, NOD, NSY and C3H mice. The sequence was also identical to the previously published sequence from a control strain, 129/J [29].…”

Section: Resultsmentioning

confidence: 69%

“…Five sets of primers were designed to cover the five exons of Txn (Table 2), according to the published genomic sequences of the 129/J strain [29]. The PCR products were purified using a QIAquickTM Gel Extraction Kit (Qiagen, Tokyo, Japan) and directly sequenced using an ABI 377 sequencer (Perkin-Elmer).…”

Section: Methodsmentioning

confidence: 99%

Sequence Analysis of Candidate Genes for Common Susceptibility to Type 1 and Type 2 Diabetes in Mice.

et al. 2001

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Abstract.Although type 1 and type 2 diabetes are regarded as clinically distinct diseases, several lines of evidence have suggested common genetic factors between the two types of diabetes. The non-obese diabetic (NOD) mouse, an animal model of type 1 diabetes, and the Nagoya-Shibata-Yasuda (NSY) mouse, a model of type 2 diabetes, are derived from the same outbred colony, Jcl:ICR, suggesting a shared susceptibility between the two types of diabetes in mice. Genetic as well as functional studies have supported the possibility that Tcf2, which encodes the transcription factor, hepatocyte nuclear factor ljS (HNF-ljl), is a candidate gene for the common susceptibility between NSY and NOD mice. Txn, encoding thioredoxin which is a redox (reduction/oxidation)-active protein, is also a positional and functional candidate for a common susceptibility gene. To investigate whether either of these two genes is a common susceptibility gene, the coding nucleotide sequences of these two genes were compared among the NSY, NOD and control C3H strains. The coding sequence of Tcf2 of the NOD mouse was identical to that of the C3H mouse, but was different from that of the NSY mouse. The coding sequence of Txn was identical in the three strains. These data suggest that neither of the two genes is a common susceptiblity gene between type 1 and type 2 diabetes in mice.

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“…The genomic sequences of PtTrxs are the first reported on the genomic structure of crustacean Trxs. Matsui et al [36] have reported that the mouse Trx1-encoding gene extends over 12 kb and consists of five exons separated by four introns. Tonissen et al [37] also reported the human Trx1 gene extends over 13 kb and consists of five exons encoding a 12-kDa protein.…”

Section: Discussionmentioning

confidence: 99%