Structure of sisomicin, a novel unsaturated aminoglycoside antibiotic from Micromonospora inyoensis

Cooper, David; Jaret, Robert S.; Reimann, Hans

doi:10.1039/c29710000285

Cited by 37 publications

(8 citation statements)

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“…Broth dilution susceptibility tests were performed with the same MuellerHinton broth media, whose magnesium content by the same method was found to range between 0. 4 In vitro killing curves in broth medium. The bactericidal activity of these antibiotics as a function of time (rate of killing curves) was assessed against two strains of each of the eight major groups of organisms studied.…”

Section: Methodsmentioning

confidence: 99%

Activity of Five Aminoglycoside Antibiotics In Vitro Against Gram-Negative Bacilli and Staphylococcus aureus

Young

Hewitt

1973

Antimicrob Agents Chemother

108

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The in vitro susceptibility to BB-K8, butirosin, gentamicin, sisomicin, and tobramycin of seven groups of clinically significant gram-negative bacilli and Staphylococcus aureus was assessed by using the International Collaborative Study-World Health Organization criteria. The activity of gentamicin, sisomicin, and tobramycin generally paralleled each other. Sisomicin was the most potent compound by weight and usually demonstrated the most rapid rate of killing. BB-K8 and butirosin were less potent, but higher serum levels may be achieved with these agents. BB-K8 generally showed the greatest ratio between achieveable mean peak serum levels and concentrations needed to inhibit [Formula: see text] of each group of organisms tested. Additionally, BB-K8 was active against six of seven highly gentamicin-resistant strains. All of these antibiotics showed diminished activity at pH 6.4 but only gentamicin and sisomicin showed occasionally enhanced activity at pH 8.4.

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Section: Methodsmentioning

confidence: 99%

Activity of Five Aminoglycoside Antibiotics In Vitro Against Gram-Negative Bacilli and Staphylococcus aureus

Young

Hewitt

1973

Antimicrob Agents Chemother

108

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“…These are tobramycin and sisomicin. Structures have been published for kanamycin (11), gentamicin (4), tobramycin (7), and sisomicin (3). Many published laboratory studies have compared gentamicin with kanamycin, and some have compared gentamicin with sisomicin (13) or gentamicin with tobramycin (5,(8)(9)(10)12).…”

mentioning

confidence: 99%

Comparative Activity of Sisomicin, Gentamicin, Kanamycin, and Tobramycin

Waitz¹,

Moss²,

Drube³

et al. 1972

Antimicrob Agents Chemother

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Gentamicin, sisomicin, tobramycin, and kanamycin were compared in parallel tests in vitro and in vivo against a variety of bacterial strains and species. A number of differences were seen in vitro, in particular: (i) the lower activity of kanamycin, (ii) the greater activity of tobramycin against Pseudomonas, (iii) the greater activity of gentamicin and sisomicin against Serratia, and (iv) the generally similar results with tobramycin, gentamicin, and sisomicin against species other than Pseudomonas and Serratia, with the ranking in order of decreasing activity being sisomicin, gentamicin, and tobramycin. Analysis of disc test results suggested that the gentamicin disc is not adequate for testing the susceptibility of all bacteria to sisomicin or tobramycin. In vivo tests did not confirm all specifics of in vitro tests; results of in vivo tests indicated that sisomicin may be the most active. It is suggested that the place of each of the antibiotics in human therapy can best be evaluated by more rigorous in vivo tests and clinical studies rather than extensive in vitro comparisons.

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“…In 3 years of marketing Messrs Merck have been informed of only four apparent skin reactions to it. Two of these patients had an allergic reaction to sorbic acid (Cooper & Wood, 1977). Sorbic acid 0-2% as contained in 'Ungentum Merck' is considered to be the antimicrobial agent of choice for topically applied vehicles and cosmetics containing fatty acids and polyoxyethylene esters (Fisher, 1973).…”

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confidence: 99%