Structure-function relationships and mode of replication of animal rhabdoviruses.

Abstract

Recently accumulated knowledge allows more precise comparison of the structural (and possibly evolutionary) relationships of several different animal rhabdoviruses: vesicular stomatitis virus, rabies virus, Kern Canyon virus, and spring viremia of carp virus.

Rabies pathogenesis

“…This subject has been reviewed in detail (11,72,83). This subject has been reviewed in detail (11,72,83).…”

Spring viraemia of carp virus: recent advances

“…The nucleotide substitution rates in the P and G genes of genogroup Ia are *3.5 times higher than in the same genes of the Id group (Padhi & Verghese, 2012). Compared with the N and G genes, the P gene exhibits a higher degree of genetic variation and is considered to be a useful marker for studying SVCV epidemiology (Sokol & Koprowski, 1975;Miller et al, 2007).…”

“…The surface G protein is the most important viral antigenic protein that determines the infectivity and serological properties of the virus (Hill et al, 1975;Bishop & Smith, 1977;Johnson et al, 1999). The N protein is a highly abundant viral protein that, in association with viral RNA, gives a helical symmetry to the nucleocapsid (Sokol & Koprowski, 1975). The P protein is a component of the nucleocapsid that interacts with N and L proteins to mediate transcription (Roy, 1981).…”

Complete Cloning and Molecular Organization of a Rabies-related Virus, Mokola Virus

“…Hybridization of ds cDNA probes, progressively covering the entire Mokola virus genome, to blots of infected cytoplasmic total RNA revealed five transcripts corresponding both in size and location to those of rabies virus . We assume therefore that the Mokola virus genome is transcribed into five monocistronic mRNAs encoding, successively from the 3' end, N, M1, M2, G and L. There is a good correlation between the protein-encoding potential of each transcript, as deduced from their electrophoretic mobility, and the measured Mr values of the proteins themselves (Sokol & Koprowski, 1975;Coslett et al, 1980). Our failure to detect plus and minus leader RNAs by Northern blot experiments suggests that their transcription could occur at a level significantly lower than in VSV (Leppert et al, 1979) as was the ca/se for measles virus (Crowley et al, 1988).…”